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Gca
Gene Detail
Symbol

Name
ID
Gca
grancalcin
MGI:1918521
Synonyms
5133401E04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
36.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:62664285-62694109 bp, + strand
From VEGA annotation of GRCm38

  29825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22702  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sorcin-like protein
Gene Tree: Gca

Human
homologs
Human Homolog GCA, grancalcin, EF-hand calcium binding protein
NCBI Gene ID 25801
neXtProt AC  NX_P28676
Human Synonyms  GCL
Human Chr (Location)  2q24.2; chr2:162318823-162379967 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
 
Mice homozygous for disruptions in this gene are essentially normal. However they do demonstrate an increased resistance to endotoxic shock.
 
Interactions
Gca interacts with 333 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis
Component cytoplasm, cytosol, ...
Function calcium-dependent cysteine-type endopeptidase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (1)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012870 (Evidence)
Ensembl Gene ModelENSMUSG00000026893 (Evidence)
Entrez Gene227960 (Evidence)
DFCITC1580523, TC1592847, TC1597779, TC1619604
DoTSDT.484960, DT.87026449, DT.94208014, DT.99623626
Consensus CDS ProjectCCDS16069.1
International Mouse Knockout Project StatusGca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012870 VEGA Gene Model | MGI Sequence Detail 29825 C57BL/6J ±  kb
transcript OTTMUST00000030860 VEGA | MGI Sequence Detail 3330 Not Applicable 
polypeptide OTTMUSP00000013828 VEGA | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000007884 grancalcin
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)
Other
accession IDs
MGI:2139004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory