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Dmrtc2 Gene Detail
Summary
  • Symbol
    Dmrtc2
  • Name
    doublesex and mab-3 related transcription factor like family C2
  • Synonyms
    4933432E21Rik, Dmrt7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918491
    NCBI Gene: 71241
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24870057-24877651 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.33 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918491
protein coding gene Chr7:24869829-24877655 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031845
protein coding gene Chr7:23280463-23287983 (+)
A/J MGP_AJ_G0031824
protein coding gene Chr7:22706971-22714481 (+)
AKR/J MGP_AKRJ_G0031753
protein coding gene Chr7:23234300-23243381 (+)
BALB/cJ MGP_BALBcJ_G0031832
protein coding gene Chr7:22912554-22920335 (+)
C3H/HeJ MGP_C3HHeJ_G0031550
protein coding gene Chr7:23650455-23659541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032293
protein coding gene Chr7:24049819-24058949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029348
protein coding gene Chr7:24141013-24148578 (+)
CAST/EiJ MGP_CASTEiJ_G0030890
protein coding gene Chr7:17128856-17136489 (+)
CBA/J MGP_CBAJ_G0031515
protein coding gene Chr7:24929193-24938935 (+)
DBA/2J MGP_DBA2J_G0031669
protein coding gene Chr7:22611773-22619664 (+)
FVB/NJ MGP_FVBNJ_G0031622
protein coding gene Chr7:22587335-22596690 (+)
LP/J MGP_LPJ_G0031748
protein coding gene Chr7:23589987-23597790 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031659
protein coding gene Chr7:24672488-24681701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032325
protein coding gene Chr7:22938261-22945739 (+)
PWK/PhJ MGP_PWKPhJ_G0030614
protein coding gene Chr7:17540475-17548194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030445
protein coding gene Chr7:14249398-14256951 (+)
WSB/EiJ MGP_WSBEiJ_G0030994
protein coding gene Chr7:23095339-23103555 (+)



Homology
more
  • Human Ortholog
    DMRTC2, DMRT like family C2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DMRTC2, DMRT like family C2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 63946
    neXtProt AC: NX_Q8IXT2
    UniProt: Q8IXT2

  • Chr Location
    19q13.2; chr19:41844743-41852330 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for a targeted allele are sterile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011349 Ensembl Gene Model | MGI Sequence Detail 7595 C57BL/6J ±  kb
    transcript ENSMUST00000011493 Ensembl | MGI Sequence Detail 1619 Not Applicable  
    polypeptide ENSMUSP00000011493 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006549 doublesex- and mab-3-related transcription factor C2
    • InterPro Domains
      IPR001275 DM DNA-binding domain
      IPR036407 DM DNA-binding domain superfamily
      IPR026607 DMRT/protein doublesex/protein male abnormal 3
      IPR031577 Doublesex- and mab-3-related transcription factor C1/C2, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
    • Latest
      J:215770 Poulain M, et al., Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. Mol Hum Reprod. 2014 Oct;20(10):960-71

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory