About   Help   FAQ
Akr1cl Gene Detail
Summary
  • Symbol
    Akr1cl
  • Name
    aldo-keto reductase family 1, member C-like
  • Synonyms
    4921521F21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918111
    NCBI Gene: 70861
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65052237-65071918 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918111
protein coding gene Chr1:65051848-65071918 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016100
protein coding gene Chr1:65198723-65222947 (-)
A/J MGP_AJ_G0016083
protein coding gene Chr1:62908931-62928967 (-)
AKR/J MGP_AKRJ_G0016040
protein coding gene Chr1:64668787-64688544 (-)
BALB/cJ MGP_BALBcJ_G0016038
protein coding gene Chr1:62999708-63024690 (-)
C3H/HeJ MGP_C3HHeJ_G0015870
protein coding gene Chr1:64942592-64962619 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016491
protein coding gene Chr1:67718444-67746074 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014212
protein coding gene Chr1:58960568-58981939 (-)
CAST/EiJ MGP_CASTEiJ_G0015453
protein coding gene Chr1:64205600-64230675 (-)
CBA/J MGP_CBAJ_G0015842
protein coding gene Chr1:69920898-69948833 (-)
DBA/2J MGP_DBA2J_G0015943
protein coding gene Chr1:62307648-62328882 (-)
FVB/NJ MGP_FVBNJ_G0015946
protein coding gene Chr1:61584413-61604529 (-)
LP/J MGP_LPJ_G0016015
protein coding gene Chr1:66101097-66121535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015966
protein coding gene Chr1:72776337-72798387 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016538
protein coding gene Chr1:64649039-64672121 (-)
PWK/PhJ MGP_PWKPhJ_G0015240
protein coding gene Chr1:61703591-61728731 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015019
protein coding gene Chr1:64129940-64154812 (-)
WSB/EiJ MGP_WSBEiJ_G0015515
protein coding gene Chr1:64358106-64379926 (-)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963262-4979967 (+)  GRCh38.p7

  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD2, DD-2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018033 (-)  GRCh38.p7

  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5048766-5107686 (+)  GRCh38.p7

  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD4, DD-4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5196835-5218947 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AKR1C2,AKR1C4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Akr1cl
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70861 NCBI Gene Model | MGI Sequence Detail 19682 C57BL/6J ±  kb
transcript NM_027582 RefSeq | MGI Sequence Detail 1376 C57BL/6  
polypeptide NP_081858 RefSeq | MGI Sequence Detail 322 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR020471 Aldo-keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR044482 Aldo-keto reductase family 1 member C
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138253, MGI:2138279
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:301697 Endo S, et al., Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity. Arch Biochem Biophys. 2019 Oct 15;674:108096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/12/2021
MGI 6.17
The Jackson Laboratory