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P2ry12
Gene Detail
 Symbol
Name
ID
P2ry12
purinergic receptor P2Y, G-protein coupled 12
MGI:1918089
Synonyms 2900079B22Rik, 4921504D23Rik, P2Y12
Feature Type protein coding gene
Genetic Map
Chromosome 3
29.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:59216271-59262831 bp, - strand
From NCBI annotation of GRCm38

  46561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: P2RY12-like receptor
Gene Tree: P2ry12

Human
homologs
Human Homolog P2RY12, purinergic receptor P2Y, G-protein coupled, 12
NCBI Gene ID 64805
neXtProt AC  NX_Q9H244
Human Synonyms  ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), SP1999
Human Chr (Location)  3q24-q25; chr3:151336843-151384812 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human P2RY12
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired platelet activation, increased bleeding time and delayed thrombus formation in injured arteries.
 
Interactions
P2ry12 interacts with 187 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process adenosine receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component basal plasma membrane, caveola, ...
Function ADP receptor activity, G-protein coupled adenosine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000036353 (Evidence)
Entrez Gene70839 (Evidence)
UniGene422675
DFCITC1585990, TC1596593, TC1624743
DoTSDT.55203248, DT.60104096
NIA Mouse Gene IndexU024092
Consensus CDS ProjectCCDS17373.1
International Mouse Knockout Project StatusP2ry12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 70839 NCBI Gene Model | MGI Sequence Detail 46561 C57BL/6J ±  kb
transcript NM_027571 RefSeq | MGI Sequence Detail 2338 C57BL/6 
polypeptide Q9CPV9 UniProt | EBI | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR005394 P2Y12 purinoceptor
Protein Ontology PR:000001569 P2Y purinoceptor 12
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209207 Wang Y, et al., Platelet P2Y12 is involved in murine pulmonary metastasis. PLoS One. 2013;8(11):e80780
All references(51)
Other
accession IDs
MGI:1920308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory