P2ry12
Gene Detail

Symbol Name ID

P2ry12 purinergic receptor P2Y, G-protein coupled 12 MGI:1918089

Synonyms

2900079B22Rik, 4921504D23Rik, P2Y12

Feature Type

protein coding gene

Genetic Map

Chromosome 3

29.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:59216271-59262831 bp, - strand From NCBI annotation of GRCm38   46561 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: P2RY12-like receptor
Gene Tree: P2ry12

Human homologs

Human Homolog		P2RY12, purinergic receptor P2Y, G-protein coupled, 12
NCBI Gene ID		64805
neXtProt AC		NX_Q9H244
Human Synonyms		ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), SP1999
Human Chr (Location)		3q24-q25; chr3:151055376-151102544 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human P2RY12

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutation of this gene results in impaired platelet activation, increased bleeding time and delayed thrombus formation in injured arteries.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	adenosine receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	basal plasma membrane, caveola, ...
Function	ADP receptor activity, G-protein coupled adenosine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000036353 (Evidence)
Entrez Gene	70839 (Evidence)
UniGene	422675
DFCI	TC1585990, TC1596593, TC1624743
DoTS	DT.55203248, DT.60104096
NIA Mouse Gene Index	U024092
Consensus CDS Project	CCDS17373.1
International Mouse Knockout Project Status	P2ry12

Sequences

Length	Strain/Species
genomic	70839	NCBI Gene Model | MGI Sequence Detail	46561	C57BL/6J
transcript	NM_027571	RefSeq | MGI Sequence Detail	2338	C57BL/6
polypeptide	Q9CPV9	UniProt | EBI | MGI Sequence Detail	347	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(322 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR002286	P2 purinoceptor
InterPro	IPR005394	P2Y12 purinoceptor
Protein Ontology	PR:000001569	P2Y purinoceptor 12

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192464 Su X, et al., The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest. 2012 Oct 1;122(10):3579-92
All references(41)

Other accession IDs

MGI:1920308