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P2ry12
Gene Detail
Symbol

Name
ID
P2ry12
purinergic receptor P2Y, G-protein coupled 12
MGI:1918089
Synonyms
2900079B22Rik, 4921504D23Rik, P2Y12
Feature Type
protein coding gene
Genetic Map
Chromosome 3
29.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:59216272-59262871 bp, - strand
From VEGA annotation of GRCm38

  46600 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11260  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: P2RY12
Protein SuperFamily: P2RY12-like receptor
Gene Tree: P2ry12

Human
homologs
P2RY12, purinergic receptor P2Y, G-protein coupled, 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64805
neXtProt AC: NX_Q9H244

Human Synonyms: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), SP1999

Human Chr (Location): 3q25.1; chr3:151336843-151384812 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human P2RY12

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired platelet activation, increased bleeding time and delayed thrombus formation in injured arteries.
 
Interactions
P2ry12 interacts with 186 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase p2ry12    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000052355 (Evidence)
Ensembl Gene Model ENSMUSG00000036353 (Evidence)
Entrez Gene 70839 (Evidence)
UniGene 422675
DFCI TC1585990, TC1596593, TC1624743
DoTS DT.55203248, DT.60104096
NIA Mouse Gene Index U024092
Consensus CDS Project CCDS17373.1
International Mouse Phenotyping Consortium Status P2ry12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052355 VEGA Gene Model | MGI Sequence Detail 46600 C57BL/6J ±  kb
transcript OTTMUST00000131397 VEGA | MGI Sequence Detail 2157 Not Applicable 
polypeptide OTTMUSP00000070264 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR005394 P2Y12 purinoceptor
Protein Ontology PR:000001569 P2Y purinoceptor 12
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215581 Eyo UB, et al., Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci. 2014 Aug 6;34(32):10528-40
All references(54)
Other
accession IDs
MGI:1920308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory