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Mutyh
Gene Detail
Symbol

Name
ID
Mutyh
mutY homolog (E. coli)
MGI:1917853
Synonyms
5730495A01Rik, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, Myh
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.34 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:116807723-116819440 bp, + strand
From VEGA annotation of GRCm38

  11718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MUTYH
Gene Tree: Mutyh

Human
homologs
MUTYH, mutY DNA glycosylase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4595
neXtProt AC: NX_Q9UIF7

Human Synonyms: MYH

Human Chr (Location): 1p34.1; chr1:45329242-45340470 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human MUTYH

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
Genomic Mutations involving Mutyh (1)
Incidental mutations (data from APF )
 
Homozygous mutant mice are viable and show no increase in tumor incidence relative to wild-type through 17 months of age.
 
Interactions
Mutyh interacts with 94 markers (Mir17, Mir20b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component mitochondrion, nucleus
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mutyh    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009751 (Evidence)
Ensembl Gene Model ENSMUSG00000028687 (Evidence)
Entrez Gene 70603 (Evidence)
UniGene 180333
DFCI TC1584651, TC1616993, TC1702140, TC1595555
DoTS DT.101735421, DT.101735422, DT.55202433, DT.40146506
NIA Mouse Gene Index U004698
EC 3.2.2.-
Consensus CDS Project CCDS18518.1
International Mouse Phenotyping Consortium Status Mutyh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009751 VEGA Gene Model | MGI Sequence Detail 11718 C57BL/6J ±  kb
transcript OTTMUST00000022543 VEGA | MGI Sequence Detail 1654 Not Applicable 
polypeptide OTTMUSP00000010281 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005760 A/G-specific adenine glycosylase MutY, bacterial form
InterPro IPR011257 DNA glycosylase
InterPro IPR004036 Endonuclease III, conserved site-2
InterPro IPR004035 Endonuclease III, iron-sulphur binding site
InterPro IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif
InterPro IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal
InterPro IPR003265 HhH-GPD domain
InterPro IPR000086 NUDIX hydrolase domain
InterPro IPR015797 NUDIX hydrolase domain-like
Protein Ontology PR:000010784 A/G-specific adenine DNA glycosylase
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:211877 Jalland CM, et al., Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage. Free Radic Biol Med. 2014 Mar;68:1-7
All references(63)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory