Mutyh
Gene Detail

Symbol Name ID

Mutyh mutY homolog (E. coli) MGI:1917853

Synonyms

5730495A01Rik, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, Myh

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.34 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:116807723-116819440 bp, + strand From VEGA annotation of GRCm38   11718 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mutyh

Human homologs

Human Homolog		MUTYH, mutY homolog (E. coli)
NCBI Gene ID		4595
neXtProt AC		NX_Q9UIF7
Human Synonyms		CYP2C, MYH
Human Chr (Location)		1p34.1; chr1:45794914-45806142 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MUTYH

Alleles and phenotypes

All alleles(28) : Targeted(5) Gene trapped(23)
 

Homozygous mutant mice are viable and show no increase in tumor incidence relative to wild-type through 17 months of age.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	base-excision repair, DNA repair, ...
Component	mitochondrion, nucleus
Function	4 iron, 4 sulfur cluster binding, catalytic activity, ...

External Resources: FuncBase

Expression

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(21)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009751 (Evidence)
Ensembl Gene Model	ENSMUSG00000028687 (Evidence)
Entrez Gene	70603 (Evidence)
UniGene	180333
DFCI	TC1584651, TC1595555, TC1616993, TC1702140
DoTS	DT.101735421, DT.101735422, DT.40146506, DT.55202433
NIA Mouse Gene Index	U004698
EC	3.2.2.-
Consensus CDS Project	CCDS18518.1
International Mouse Knockout Project Status	Mutyh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009751	VEGA Gene Model | MGI Sequence Detail	11718	C57BL/6J
transcript	OTTMUST00000022543	VEGA | MGI Sequence Detail	1654	Not Applicable
polypeptide	OTTMUSP00000010281	VEGA | MGI Sequence Detail	515	Not Applicable

All sequences(59) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005760	A/G-specific adenine glycosylase MutY, bacterial form
InterPro	IPR011257	DNA glycosylase
InterPro	IPR004036	Endonuclease III, conserved site-2
InterPro	IPR004035	Endonuclease III, iron-sulphur binding site
InterPro	IPR003651	Endonuclease III-like, iron-sulphur cluster loop motif
InterPro	IPR023170	Helix-turn-helix, base-excision DNA repair, C-terminal
InterPro	IPR003265	HhH-GPD domain
InterPro	IPR000086	NUDIX hydrolase domain
InterPro	IPR015797	NUDIX hydrolase domain-like
Protein Ontology	PR:000010784	A/G-specific adenine DNA glycosylase

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193978 Sheng Z, et al., 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair. J Clin Invest. 2012 Dec 3;122(12):4344-61
All references(59)