Wars2
Gene Detail

Symbol Name ID

Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) MGI:1917810

Synonyms

9430020O07Rik, TrpRS

Feature Type

protein coding gene

Genetic Map

Chromosome 3

43.03 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:99141068-99239186 bp, + strand From VEGA annotation of GRCm38   98119 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tryptophan-tRNA ligase
Gene Tree: Wars2

Human homologs

Human Homolog		WARS2, tryptophanyl tRNA synthetase 2, mitochondrial
NCBI Gene ID		10352
neXtProt AC		NX_Q9UGM6
Human Synonyms		TrpRS
Human Chr (Location)		1p12; chr1:119573839-119683295 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	translation, tRNA aminoacylation for protein translation, ...
Component	cytoplasm, mitochondrion
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (9)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) cDNA(34)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006862 (Evidence)
Ensembl Gene Model	ENSMUSG00000004233 (Evidence)
Entrez Gene	70560 (Evidence)
UniGene	316754
DFCI	TC1582420, TC1662996
DoTS	DT.111054966, DT.55141637, DT.55270283
NIA Mouse Gene Index	U003628
EC	6.1.1.2
Consensus CDS Project	CCDS17672.1
International Mouse Knockout Project Status	Wars2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006862	VEGA Gene Model | MGI Sequence Detail	98119	C57BL/6J
transcript	OTTMUST00000015865	VEGA | MGI Sequence Detail	4410	Not Applicable
polypeptide	OTTMUSP00000007286	VEGA | MGI Sequence Detail	360	Not Applicable

All sequences(34) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(456 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002305	Aminoacyl-tRNA synthetase, class Ic
InterPro	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
InterPro	IPR002306	Tryptophan-tRNA ligase
InterPro	IPR024109	Tryptophan-tRNA ligase, bacterial-type
Protein Ontology	PR:000017370	tryptophanyl-tRNA synthetase, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:155529 Wakasugi K, Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. FEBS Lett. 2010 Jan 4;584(1):229-32
All references(36)

Other accession IDs

MGI:1924510, MGI:2139688