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Qpct
Gene Detail
 Symbol
Name
ID
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
MGI:1917786
Synonyms 5730422A13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
49.83 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:79051906-79090243 bp, + strand
From NCBI annotation of GRCm38

  38338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

Gene Tree: Qpct

Human
homologs
Human Homolog QPCT, glutaminyl-peptide cyclotransferase
NCBI Gene ID 25797
neXtProt AC  NX_Q16769
Human Synonyms  GCT, QC, sQC
Human Chr (Location)  2p22.2; chr2:37344610-37373322 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice exhibit normal motor coordination and spatial working memory.
 
Interactions
Qpct interacts with 80 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Component extracellular region, extracellular vesicular exosome
Function glutaminyl-peptide cyclotransferase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (99)    Images (26)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 135
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024084 (Evidence)
Entrez Gene70536 (Evidence)
UniGene293870
DFCITC1577636, TC1592367
DoTSDT.101369871, DT.50315539
NIA Mouse Gene IndexU018243
EC2.3.2.5
PDB3SI1, 3SI2
Consensus CDS ProjectCCDS28983.1
International Mouse Knockout Project StatusQpct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 70536 NCBI Gene Model | MGI Sequence Detail 38338 C57BL/6J ±  kb
transcript NM_027455 RefSeq | MGI Sequence Detail 1924 C57BL/6 
polypeptide Q9CYK2 UniProt | EBI | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(581 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007484 Peptidase M28
Protein Ontology PR:000013565 glutaminyl-peptide cyclotransferase
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory