Qpct
Gene Detail

Symbol Name ID

Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase) MGI:1917786

Synonyms

5730422A13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

49.83 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:79051906-79090243 bp, + strand From NCBI annotation of GRCm38   38338 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Qpct

Human homologs

Human Homolog		QPCT, glutaminyl-peptide cyclotransferase
NCBI Gene ID		25797
neXtProt AC		NX_Q16769
Human Synonyms		GCT, QC, sQC
Human Chr (Location)		2p22.2; chr2:37571753-37600465 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice exhibit normal motor coordination and spatial working memory.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase, proteolysis
Component	extracellular region
Function	glutaminyl-peptide cyclotransferase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (99)    Images (26)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	135

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024084 (Evidence)
Entrez Gene	70536 (Evidence)
UniGene	293870
DFCI	TC1577636, TC1592367
DoTS	DT.101369871, DT.50315539
NIA Mouse Gene Index	U018243
EC	2.3.2.5
PDB	3SI1, 3SI2
Consensus CDS Project	CCDS28983.1
International Mouse Knockout Project Status	Qpct

Sequences

Length	Strain/Species
genomic	70536	NCBI Gene Model | MGI Sequence Detail	38338	C57BL/6J
transcript	NM_027455	RefSeq | MGI Sequence Detail	1924	C57BL/6
polypeptide	Q9CYK2	UniProt | EBI | MGI Sequence Detail	362	Not Applicable

All sequences(24) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(270 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007484	Peptidase M28
Protein Ontology	PR:000013565	glutaminyl-peptide cyclotransferase

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All references(33)