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Crtc3 Gene Detail
Summary
  • Symbol
    Crtc3
  • Name
    CREB regulated transcription coactivator 3
  • Synonyms
    2610312F20Rik, 6332415K15Rik, MGC:19083
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917711
    NCBI Gene: 70461
  • Gene Overview
    MyGene.info: CRTC3
Location & Maps
more
  • Sequence Map
    Chr7:80586627-80688877 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102251 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.65 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
    Orthology source: HomoloGene
  • Synonyms
    TORC3, TORC-3
  • Links
    NCBI Gene ID: 64784
    neXtProt AC: NX_Q6UUV7

  • Chr Location
    15q26.1; chr15:90529886-90645345 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Crtc3
  • Incidental Mutations
Mice homozygous for a null mutation display resistance to diet-induced obesity, increased energy expenditure, decreased white adipose tissue mass, increased brown adipose cell numbers, and increased core temperature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027172 VEGA Gene Model | MGI Sequence Detail 102251 C57BL/6J ±  kb
transcript OTTMUST00000067206 VEGA | MGI Sequence Detail 5115 Not Applicable  
polypeptide OTTMUSP00000033783 VEGA | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    817 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005903 CREB-regulated transcription coactivator 3
  • InterPro Domains
    IPR024786 CREB-regulated transcription coactivator
    IPR024785 Transducer of regulated CREB activity, C-terminal
    IPR024784 Transducer of regulated CREB activity, middle domain
    IPR024783 Transducer of regulated CREB activity, N-terminal
Molecular
Reagents
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  • All nucleic 42
    cDNA 42

    Microarray probesets 4
Other
Accession IDs
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MGI:2141955, MGI:2444551, MGI:2447777
References
more
  • Summaries
    All 35
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228308 Luan B, et al., CREB pathway links PGE2 signaling with macrophage polarization. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15642-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory