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Crtc3
Gene Detail
Symbol

Name
ID
Crtc3
CREB regulated transcription coactivator 3
MGI:1917711
Synonyms
2610312F20Rik, 6332415K15Rik, MGC:19083
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:80586627-80688877 bp, - strand
From VEGA annotation of GRCm38

  102251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRTC3
Gene Tree: Crtc3

Human
homologs
CRTC3, CREB regulated transcription coactivator 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64784
neXtProt AC: NX_Q6UUV7

Human Synonyms: TORC3, TORC-3

Human Chr (Location): 15q26.1; chr15:90529886-90645345 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display resistance to diet-induced obesity, increased energy expenditure, decreased white adipose tissue mass, increased brown adipose cell numbers, and increased core temperature.
 
Interactions
Crtc3 interacts with 315 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process energy homeostasis, macrophage activation, ...
Component cytoplasm, nucleoplasm, ...
Function cAMP response element binding protein binding
External Resources: FuncBase
Expression
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crtc3 ; ZFIN crtc3    NEW 
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027172 (Evidence)
Ensembl Gene Model ENSMUSG00000030527 (Evidence)
Entrez Gene 70461 (Evidence)
UniGene 392175
DFCI TC1584434, TC1597596, TC1611054
DoTS DT.101329437, DT.101714728, DT.529251
NIA Mouse Gene Index U028768
Consensus CDS Project CCDS21398.2
International Mouse Phenotyping Consortium Status Crtc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027172 VEGA Gene Model | MGI Sequence Detail 102251 C57BL/6J ±  kb
transcript OTTMUST00000067206 VEGA | MGI Sequence Detail 5115 Not Applicable 
polypeptide OTTMUSP00000033783 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(826 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024786 CREB-regulated transcription coactivator
InterPro IPR024785 Transducer of regulated CREB activity, C-terminal
InterPro IPR024784 Transducer of regulated CREB activity, middle domain
InterPro IPR024783 Transducer of regulated CREB activity, N-terminal
Protein Ontology PR:000005903 CREB-regulated transcription coactivator 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215277 Luan B, et al., Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 2014 Jun 3;19(6):1058-65
All references(37)
Other
accession IDs
MGI:2141955, MGI:2444551, MGI:2447777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory