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Crtc3
Gene Detail
 Symbol
Name
ID
Crtc3
CREB regulated transcription coactivator 3
MGI:1917711
Synonyms 2610312F20Rik, 6332415K15Rik, MGC:19083
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:80586627-80688877 bp, - strand
From VEGA annotation of GRCm38

  102251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Crtc3

Human
homologs
Human Homolog CRTC3, CREB regulated transcription coactivator 3
NCBI Gene ID 64784
neXtProt AC  NX_Q6UUV7
Human Synonyms  TORC3, TORC-3
Human Chr (Location)  15q26.1; chr15:90529886-90645345 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display resistance to diet-induced obesity, increased energy expenditure, decreased white adipose tissue mass, increased brown adipose cell numbers, and increased core temperature.
 
Interactions
Crtc3 interacts with 315 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process energy homeostasis, negative regulation of cAMP-mediated signaling, ...
Component cytoplasm, nucleus
Function cAMP response element binding protein binding
External Resources: FuncBase
Expression
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027172 (Evidence)
Ensembl Gene ModelENSMUSG00000030527 (Evidence)
Entrez Gene70461 (Evidence)
UniGene392175
DFCITC1584434, TC1597596, TC1611054
DoTSDT.101329437, DT.101714728, DT.529251
NIA Mouse Gene IndexU028768
Consensus CDS ProjectCCDS21398.2
International Mouse Knockout Project StatusCrtc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027172 VEGA Gene Model | MGI Sequence Detail 102251 C57BL/6J ±  kb
transcript OTTMUST00000067206 VEGA | MGI Sequence Detail 5115 Not Applicable 
polypeptide OTTMUSP00000033783 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(826 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024786 Transducer of regulated CREB activity
InterPro IPR024785 Transducer of regulated CREB activity, C-terminal
InterPro IPR024784 Transducer of regulated CREB activity, middle domain
InterPro IPR024783 Transducer of regulated CREB activity, N-terminal
Protein Ontology PR:000005903 CREB-regulated transcription coactivator 3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2141955, MGI:2444551, MGI:2447777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory