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Crtc3 Gene Detail
Summary
  • Symbol
    Crtc3
  • Name
    CREB regulated transcription coactivator 3
  • Synonyms
    2610312F20Rik, 6332415K15Rik, MGC:19083
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917711
    NCBI Gene: 70461
  • Gene Overview
    MyGene.info: CRTC3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80586627-80688877 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    817 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917711
protein coding gene Chr7:80586627-80688942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032417
protein coding gene Chr7:82565931-82676365 (-)
A/J MGP_AJ_G0032396
protein coding gene Chr7:80637358-80741774 (-)
AKR/J MGP_AKRJ_G0032332
protein coding gene Chr7:82399083-82509265 (-)
BALB/cJ MGP_BALBcJ_G0032408
protein coding gene Chr7:80310903-80415378 (-)
C3H/HeJ MGP_C3HHeJ_G0032121
protein coding gene Chr7:83029082-83135911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032900
protein coding gene Chr7:85806443-85912157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029908
protein coding gene Chr7:83155117-83259569 (-)
CAST/EiJ MGP_CASTEiJ_G0031449
protein coding gene Chr7:73923336-74033438 (-)
CBA/J MGP_CBAJ_G0032087
protein coding gene Chr7:88657974-88768434 (-)
DBA/2J MGP_DBA2J_G0032242
protein coding gene Chr7:79192486-79296465 (-)
FVB/NJ MGP_FVBNJ_G0032197
protein coding gene Chr7:79116319-79222186 (-)
LP/J MGP_LPJ_G0032323
protein coding gene Chr7:83805013-83915115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032234
protein coding gene Chr7:88800953-88909114 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032918
protein coding gene Chr7:81821107-81931340 (-)
PWK/PhJ MGP_PWKPhJ_G0031169
protein coding gene Chr7:72386341-72491741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031010
protein coding gene Chr7:68826971-68932268 (-)
WSB/EiJ MGP_WSBEiJ_G0031567
protein coding gene Chr7:82178790-82291096 (-)



Homology
more
  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRTC3, CREB regulated transcription coactivator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TORC3, TORC-3
  • Links
    NCBI Gene ID: 64784
    neXtProt AC: NX_Q6UUV7
    UniProt: Q6UUV7

  • Chr Location
    15q26.1; chr15:90529886-90645345 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display resistance to diet-induced obesity, increased energy expenditure, decreased white adipose tissue mass, increased brown adipose cell numbers, and increased core temperature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030527 Ensembl Gene Model | MGI Sequence Detail 102251 C57BL/6J ±  kb
transcript ENSMUST00000122255 Ensembl | MGI Sequence Detail 5115 Not Applicable  
polypeptide ENSMUSP00000113540 Ensembl | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005903 CREB-regulated transcription coactivator 3
  • InterPro Domains
    IPR024786 CREB-regulated transcription coactivator
    IPR024785 Transducer of regulated CREB activity, C-terminal
    IPR024784 Transducer of regulated CREB activity, middle domain
    IPR024783 Transducer of regulated CREB activity, N-terminal
Molecular
Reagents
less
  • All nucleic 44
    cDNA 44

    Microarray probesets 4
Other
Accession IDs
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MGI:2141955, MGI:2444551, MGI:2447777
References
more
  • Summaries
    All 52
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:263015 Yoon YS, et al., cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5289-E5297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory