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Yars2
Gene Detail
Symbol

Name
ID
Yars2
tyrosyl-tRNA synthetase 2 (mitochondrial)
MGI:1917370
Synonyms
2210023C10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:16302965-16309640 bp, + strand
From VEGA annotation of GRCm38

  6676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Yars2

Human
homologs
Human Homolog YARS2, tyrosyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID 51067
neXtProt AC  NX_Q9Y2Z4
Human Synonyms  MLASA2, MT-TYRRS, TYRRS
Human Chr (Location)  12p11.21; chr12:32725361-32755961 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human YARS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Yars2 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process mitochondrial tyrosyl-tRNA aminoacylation, translation, ...
Component cytoplasm, mitochondrion
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (156)    Tissues (103)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(35)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026531 (Evidence)
Ensembl Gene ModelENSMUSG00000022792 (Evidence)
Entrez Gene70120 (Evidence)
UniGene37486
DFCITC1578616, TC1588511
DoTSDT.101362235, DT.110732284, DT.40136575, DT.485757, DT.94245366
NIA Mouse Gene IndexU016854
EC6.1.1.1
Consensus CDS ProjectCCDS27983.1
International Mouse Knockout Project StatusYars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026531 VEGA Gene Model | MGI Sequence Detail 6676 C57BL/6J ±  kb
transcript OTTMUST00000065640 VEGA | MGI Sequence Detail 1574 Not Applicable 
polypeptide OTTMUSP00000032741 VEGA | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(3) UniProt(5)
Polymorphisms
SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002305 Aminoacyl-tRNA synthetase, class Ic
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR002942 RNA-binding S4 domain
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR002307 Tyrosine-tRNA ligase
InterPro IPR024088 Tyrosine-tRNA ligase, bacterial-type
Protein Ontology PR:000017524 tyrosine--tRNA ligase, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGI:2146633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory