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Rab28 Gene Detail
Summary
  • Symbol
    Rab28
  • Name
    RAB28, member RAS oncogene family
  • Synonyms
    2700023P08Rik, MGC:8039
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917285
    NCBI Gene: 100972
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:41624976-41708157 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 22.58 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917285
 protein coding gene Chr5:41624973-41708193 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029517
 protein coding gene Chr5:40201781-40288430 (-)
A/J MGP_AJ_G0029483
 protein coding gene Chr5:38843955-38941731 (-)
AKR/J MGP_AKRJ_G0029433
 protein coding gene Chr5:40246827-40329379 (-)
BALB/cJ MGP_BALBcJ_G0029494
 protein coding gene Chr5:39287358-39375647 (-)
C3H/HeJ MGP_C3HHeJ_G0029217
 protein coding gene Chr5:40235423-40327128 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029948
 protein coding gene Chr5:42205133-42324388 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027186
 protein coding gene Chr5:36243719-36329232 (-)
CAST/EiJ MGP_CASTEiJ_G0028625
 protein coding gene Chr5:39352119-39439545 (-)
CBA/J MGP_CBAJ_G0029184
 protein coding gene Chr5:43279361-43367287 (-)
DBA/2J MGP_DBA2J_G0029331
 protein coding gene Chr5:38920570-39008931 (-)
FVB/NJ MGP_FVBNJ_G0029290
 protein coding gene Chr5:38368166-38455084 (-)
LP/J MGP_LPJ_G0029417
 protein coding gene Chr5:40637377-40726074 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029320
 protein coding gene Chr5:44092313-44212568 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029981
 protein coding gene Chr5:39740742-39819974 (-)
PWK/PhJ MGP_PWKPhJ_G0028349
 protein coding gene Chr5:38091213-38184473 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028183
 protein coding gene Chr5:39233136-39322121 (-)
WSB/EiJ MGP_WSBEiJ_G0028706
 protein coding gene Chr5:39794594-39879499 (-)



Homology
more
  • Human Ortholog
    RAB28, RAB28, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB28, RAB28, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CORD18
  • Links
    NCBI Gene ID: 9364
    neXtProt AC: NX_P51157
    UniProt: P51157

  • Chr Location
    4p15.33; chr4:13293479-13484365 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Rab28 mouse models; 1 with human RAB28 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced cone and rod ERG responses, defects in cone-specific disc shedding and phagocytosis, and progressive retina degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    9
  • cDNA Data
    73
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029128 Ensembl Gene Model | MGI Sequence Detail 83182 C57BL/6J ±  kb
    transcript ENSMUST00000031011 Ensembl | MGI Sequence Detail 1635 Not Applicable  
    polypeptide ENSMUSP00000031011 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141204
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory