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Mcm10
Gene Detail
Symbol

Name
ID
Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
MGI:1917274
Synonyms
2410041F14Rik, C330019M07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
3.12 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:4989714-5012791 bp, - strand
From VEGA annotation of GRCm38

  23078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCM10
Gene Tree: Mcm10

Human
homologs
MCM10, minichromosome maintenance complex component 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55388
neXtProt AC: NX_Q7L590

Human Synonyms: CNA43, DNA43, PRO2249

Human Chr (Location): 10p13; chr10:13161554-13211104 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(38) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit reduced embryonic cell proliferation and early embryonic letahlity.
 
Interactions
Mcm10 interacts with 186 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell proliferation, DNA replication, ...
Component cytoplasm, nucleolus, ...
Function DNA binding, DNA replication origin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (45)    Tissues (24)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 44
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mcm10    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010867 (Evidence)
Ensembl Gene Model ENSMUSG00000026669 (Evidence)
Entrez Gene 70024 (Evidence)
DFCI TC1590930, TC1610144, TC1575780, TC1694672
DoTS DT.101142198, DT.40148037, DT.97382046, DT.101398560, DT.101309224, DT.101370096, DT.530972
NIA Mouse Gene Index U022251
Consensus CDS Project CCDS15662.1
International Mouse Phenotyping Consortium Status Mcm10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010867 VEGA Gene Model | MGI Sequence Detail 23078 C57BL/6J ±  kb
transcript OTTMUST00000025429 VEGA | MGI Sequence Detail 4867 Not Applicable 
polypeptide OTTMUSP00000011652 VEGA | MGI Sequence Detail 885 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(274 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015411 Replication factor Mcm10
InterPro IPR015408 Zinc finger, Mcm10/DnaG-type
Protein Ontology PR:000010241 protein MCM10
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
All references(39)
Other
accession IDs
MGI:1925780, MGI:2139167, MGI:2139484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory