Nt5dc2 MGI Mouse Gene Detail - MGI:1917271 - 5'-nucleotidase domain containing 2

Symbol

Nt5dc2
Name

5'-nucleotidase domain containing 2
Synonyms

2510015F01Rik

Feature Type

protein coding gene
IDs

MGI:1917271
NCBI Gene: 70021
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:31131053-31139124 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.09 cM
Mapping Data

1 experiment

SNPs within 2kb

14 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917271	protein coding gene	Chr14:31130806-31139124 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021119	protein coding gene	Chr14:24301972-24311459 (+)
A/J	MGP_AJ_G0021067	protein coding gene	Chr14:23385161-23392874 (+)
AKR/J	MGP_AKRJ_G0021044	protein coding gene	Chr14:24509074-24516842 (+)
BALB/cJ	MGP_BALBcJ_G0021071	protein coding gene	Chr14:23506615-23514511 (+)
C3H/HeJ	MGP_C3HHeJ_G0020854	protein coding gene	Chr14:24378347-24382444 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021503	protein coding gene	Chr14:25274434-25281579 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019066	protein coding gene	Chr14:23448081-23455992 (+)
CAST/EiJ	MGP_CASTEiJ_G0020379	protein coding gene	Chr14:24141093-24149624 (+)
CBA/J	MGP_CBAJ_G0020821	protein coding gene	Chr14:26247633-26253905 (+)
DBA/2J	MGP_DBA2J_G0020943	protein coding gene	Chr14:23414724-23422554 (+)
FVB/NJ	MGP_FVBNJ_G0020927	protein coding gene	Chr14:23380618-23384971 (+)
LP/J	MGP_LPJ_G0021012	protein coding gene	Chr14:24629008-24638668 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020953	protein coding gene	Chr14:25513138-25518726 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021536	protein coding gene	Chr14:24273288-24277506 (+)
PWK/PhJ	MGP_PWKPhJ_G0020127	protein coding gene	Chr14:22870430-22878132 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019951	protein coding gene	Chr14:23866132-23873887 (+)
WSB/EiJ	MGP_WSBEiJ_G0020434	protein coding gene	Chr14:24328377-24336172 (+)

Human Ortholog

NT5DC2, 5'-nucleotidase domain containing 2

Vertebrate Orthologs

9

Human Ortholog

NT5DC2, 5'-nucleotidase domain containing 2
Orthology source: HomoloGene, HGNC
Links

HGNC:25717

NCBI Gene ID: 64943

neXtProt AC: NX_Q9H857

UniProt: Q9H857
Chr Location

3p21.1; chr3:52524369-52535077 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11290
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NT5DC2
Protein SuperFamily

cytosolic purine 5'-nucleotidase
Gene Tree

Nt5dc2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

2
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

144
Tissues

23
cDNA Data

98
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nt5dc2

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Nt5dc2 interacts with 8 markers (Mir128-2, Mir137, Mir293, ...) View All

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All Sequences

45
RefSeq

4
UniProt

6
CCDS

CCDS36852.1
UniGene

261681

Ensembl

ENSMUSG00000071547 (Evidence)
NCBI Gene

70021

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071547	Ensembl Gene Model \| MGI Sequence Detail	8072	C57BL/6J	± kb
transcript	ENSMUST00000227096	Ensembl \| MGI Sequence Detail	1848	Not Applicable
polypeptide	ENSMUSP00000154475	Ensembl \| MGI Sequence Detail	553	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR008380 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase

IPR016695 Purine 5'-nucleotidase

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All nucleic 100

cDNA 98

Primer pair 2

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:198109 Oeschger FM, et al., Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59

TSS for Nt5dc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124918	Chr14:31134730-31134765 (+)	3,695 bp
Tssr124920	Chr14:31138061-31138086 (+)	7,021 bp
Tssr124921	Chr14:31138325-31138348 (+)	7,284 bp
Tssr124922	Chr14:31138358-31138375 (+)	7,314 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/13/2019 MGI 6.13