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Tnik
Gene Detail
Symbol

Name
ID
Tnik
TRAF2 and NCK interacting kinase
MGI:1916264
Synonyms
1500031A17Rik, 4831440I19Rik, C530008O15Rik, C630040K21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
11.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:28263214-28675858 bp, + strand
From VEGA annotation of GRCm38

  412645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77943  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tnik

Human
homologs
Human Homolog TNIK, TRAF2 and NCK interacting kinase
NCBI Gene ID 23043
neXtProt AC  NX_Q9UKE5
Human Chr (Location)  3q26.31; chr3:171062503-171460408 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function.
 
Interactions
Tnik interacts with 579 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process actin cytoskeleton reorganization, activation of JNKK activity, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030434 VEGA Gene Model | MGI Sequence Detail 412645 C57BL/6J ±  kb
transcript OTTMUST00000075383 VEGA | MGI Sequence Detail 4404 Not Applicable 
polypeptide OTTMUSP00000039499 VEGA | MGI Sequence Detail 1360 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(18) UniProt(25)
Polymorphisms
SNPs within 2kb(2812 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016491 TRAF2 and NCK-interacting protein kinase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190924 Coba MP, et al., TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci. 2012 Oct 3;32(40):13987-99
All references(37)
Other
accession IDs
MGI:1925958, MGI:2139720, MGI:2441673, MGI:2444917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory