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Tnik
Gene Detail
 Symbol
Name
ID
Tnik
TRAF2 and NCK interacting kinase
MGI:1916264
Synonyms 1500031A17Rik, 4831440I19Rik, C530008O15Rik, C630040K21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
11.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:28263214-28675858 bp, + strand
From VEGA annotation of GRCm38

  412645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77943  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Tnik

Human
homologs
Human Homolog TNIK, TRAF2 and NCK interacting kinase
NCBI Gene ID 23043
neXtProt AC  NX_Q9UKE5
Human Chr (Location)  3q26.31; chr3:171062503-171460408 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process actin cytoskeleton reorganization, activation of JNKK activity, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000030434 (Evidence)
Ensembl Gene ModelENSMUSG00000027692 (Evidence)
Entrez Gene665113 (Evidence)
DFCITC1581833, TC1597198, TC1599045, TC1600837, TC1613177, TC1615072, TC1622222, TC1631178, TC1672138
DoTSDT.101122970, DT.101138640, DT.101243144, DT.101355423, DT.101370917, DT.101370918, DT.524635, DT.55201135, DT.91330038, DT.94134120
NIA Mouse Gene IndexU042415
EC2.7.11.1
Consensus CDS ProjectCCDS50877.1, CCDS50878.1, CCDS50879.1
International Mouse Knockout Project StatusTnik
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030434 VEGA Gene Model | MGI Sequence Detail 412645 C57BL/6J ±  kb
transcript OTTMUST00000075383 VEGA | MGI Sequence Detail 4404 Not Applicable 
polypeptide OTTMUSP00000039499 VEGA | MGI Sequence Detail 1360 Not Applicable 

For the selected sequences
All sequences(133) RefSeq(18) UniProt(13)
Polymorphisms SNPs within 2kb(2812 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016491 TRAF2 and NCK-interacting protein kinase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190924 Coba MP, et al., TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. J Neurosci. 2012 Oct 3;32(40):13987-99
All references(37)
Other
accession IDs
MGI:1925958, MGI:2139720, MGI:2441673, MGI:2444917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory