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Pink1
Gene Detail
Symbol

Name
ID
Pink1
PTEN induced putative kinase 1
MGI:1916193
Synonyms
1190006F07Rik, brpk
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:138313409-138326307 bp, - strand
From VEGA annotation of GRCm38

  12899 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pink1

Human
homologs
Human Homolog PINK1, PTEN induced putative kinase 1
NCBI Gene ID 65018
neXtProt AC  NX_Q9BXM7
Human Synonyms  BRPK, PARK6
Human Chr (Location)  1p36; chr1:20633455-20651511 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PINK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Some mice homozygous for null mutations exhibit decreased dopamine content, reduced long term potentional and depression, mitochondrial abnormalities, and/or behavioral abnormalities. Some null mice model the early stages of Parkinson Disease.
 
Human Diseases Modeled Using Mouse Pink1 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Pink1 interacts with 65 markers (Mir18, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process autophagy, cellular response to hypoxia, ...
Component astrocyte projection, axon, ...
Function ATP binding, C3HC4-type RING finger domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (138)    Tissues (102)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
cDNA source data(196)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(197) cDNA(196) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009975 (Evidence)
Ensembl Gene ModelENSMUSG00000028756 (Evidence)
Entrez Gene68943 (Evidence)
UniGene18539
DFCITC1572142, TC1731340, TC1767303
DoTSDT.103564506, DT.110792392, DT.534899
NIA Mouse Gene IndexU025686
EC2.7.11.1
Consensus CDS ProjectCCDS18825.1
International Mouse Knockout Project StatusPink1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009975 VEGA Gene Model | MGI Sequence Detail 12899 C57BL/6J ±  kb
transcript OTTMUST00000023184 VEGA | MGI Sequence Detail 2375 Not Applicable 
polypeptide OTTMUSP00000010580 VEGA | MGI Sequence Detail 580 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(2) UniProt(11)
Polymorphisms
SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012737 serine/threonine-protein kinase PINK1, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:214065 Gispert S, et al., Potentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet. 2014 Oct 8;
All references(77)
Disease annotation references (5)
Other
accession IDs
MGI:2140484, MGI:2140604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory