Pink1
Gene Detail

Symbol Name ID

Pink1 PTEN induced putative kinase 1 MGI:1916193

Synonyms

1190006F07Rik, brpk

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:138313409-138326307 bp, - strand From VEGA annotation of GRCm38   12899 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pink1

Human homologs

Human Homolog		PINK1, PTEN induced putative kinase 1
NCBI Gene ID		65018
neXtProt AC		NX_Q9BXM7
Human Synonyms		BRPK, PARK6
Human Chr (Location)		1p36; chr1:20959948-20978004 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PINK1

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Some mice homozygous for null mutations exhibit decreased dopamine content, reduced long term potentional and depression, mitochondrial abnormalities, and/or behavioral abnormalities. Some null mice model the early stages of Parkinson Disease.

 
Human Diseases Modeled Using Mouse Pink1 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	autophagy, cellular response to toxic substance, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, C3HC4-type RING finger domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (138)    Tissues (102)    Images (28)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	138

cDNA source data(196)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(197) cDNA(196) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000009975 (Evidence)
Ensembl Gene Model	ENSMUSG00000028756 (Evidence)
Entrez Gene	68943 (Evidence)
UniGene	18539
DFCI	TC1572142, TC1731340, TC1767303
DoTS	DT.103564506, DT.110792392, DT.534899
NIA Mouse Gene Index	U025686
EC	2.7.11.1
Consensus CDS Project	CCDS18825.1
International Mouse Knockout Project Status	Pink1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009975	VEGA Gene Model | MGI Sequence Detail	12899	C57BL/6J
transcript	OTTMUST00000023184	VEGA | MGI Sequence Detail	2375	Not Applicable
polypeptide	OTTMUSP00000010580	VEGA | MGI Sequence Detail	580	Not Applicable

All sequences(70) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012737	serine/threonine-protein kinase PINK1, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(65)

Other accession IDs

MGI:2140484, MGI:2140604