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Urah
Gene Detail
Symbol

Name
ID
Urah
urate (5-hydroxyiso-) hydrolase
MGI:1916142
Synonyms
1190003J15Rik, 2810420C16Rik, HIU hydrolase
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:140835018-140837971 bp, + strand
From VEGA annotation of GRCm38

  2954 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45975  Vertebrate Homology Class
1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: URAHP
Protein SuperFamily: transthyretin/transthyretin-related protein
Gene Tree: Urah

Human
homologs
URAHP, urate (hydroxyiso-) hydrolase, pseudogene
Orthology source: HGNC

IDs:
NCBI Gene ID: 100130015

Human Synonyms: URAH

Human Chr (Location): 16q24.3; chr16:90039761-90047783 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU mutation have an elevated platelet cell number, display hepatomegaly and hepatocellular carcinoma.
 
Interactions
Urah interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process purine nucleobase metabolic process
Component mitochondrion, peroxisome
Function hydrolase activity, hydroxyisourate hydrolase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024526 (Evidence)
Ensembl Gene Model ENSMUSG00000025481 (Evidence)
Entrez Gene 76974 (Evidence)
DFCI TC1582402
DoTS DT.532352, DT.94234306
NIA Mouse Gene Index U040692
EC 3.5.2.17
Consensus CDS Project CCDS21986.1
International Mouse Phenotyping Consortium Status Urah
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024526 VEGA Gene Model | MGI Sequence Detail 2954 C57BL/6J ±  kb
transcript OTTMUST00000060193 VEGA | MGI Sequence Detail 719 Not Applicable 
polypeptide OTTMUSP00000029354 VEGA | MGI Sequence Detail 141 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014306 Hydroxyisourate hydrolase
InterPro IPR023419 Transthyretin, conserved site
InterPro IPR000895 Transthyretin/hydroxyisourate hydrolase
InterPro IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily
Protein Ontology PR:000017227 5-hydroxyisourate hydrolase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:1924224

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory