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Arel1
Gene Detail
 Symbol
Name
ID
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
MGI:1915747
Synonyms 1110018G07Rik, mKIAA0317
Feature Type protein coding gene
Genetic Map
Chromosome 12
39.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:84918148-84970900 bp, - strand
From VEGA annotation of GRCm38

  52753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arel1

Human
homologs
Human Homolog AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
NCBI Gene ID 9870
neXtProt AC  NX_O15033
Human Synonyms  KIAA0317
Human Chr (Location)  14q24.3; chr14:74661252-74713115 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arel1 interacts with 408 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process apoptotic process, negative regulation of apoptotic process, ...
Component cytoplasm, cytosol, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035485 (Evidence)
Ensembl Gene ModelENSMUSG00000042350 (Evidence)
Entrez Gene68497 (Evidence)
DFCITC1574686, TC1602602, TC1603099
DoTSDT.101289690, DT.110941073, DT.528958, DT.91586645, DT.94220778
NIA Mouse Gene IndexU034177
EC6.3.2.-
Consensus CDS ProjectCCDS26051.1
International Mouse Knockout Project StatusArel1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035485 VEGA Gene Model | MGI Sequence Detail 52753 C57BL/6J ±  kb
transcript OTTMUST00000090852 VEGA | MGI Sequence Detail 5446 Not Applicable 
polypeptide OTTMUSP00000049942 VEGA | MGI Sequence Detail 823 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(8) UniProt(9)
Polymorphisms SNPs within 2kb(288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR000569 HECT
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198601 Kim JB, et al., Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21
All references(29)
Other
accession IDs
MGI:2144874, MGI:2145051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory