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Arel1
Gene Detail
Symbol

Name
ID
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
MGI:1915747
Synonyms
1110018G07Rik, mKIAA0317
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:84918148-84970900 bp, - strand
From VEGA annotation of GRCm38

  52753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AREL1
Gene Tree: Arel1

Human
homologs
AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9870
neXtProt AC: NX_O15033

Human Synonyms: KIAA0317

Human Chr (Location): 14q24.3; chr14:74661252-74713115 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Arel1 interacts with 407 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arel1    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035485 (Evidence)
Ensembl Gene Model ENSMUSG00000042350 (Evidence)
Entrez Gene 68497 (Evidence)
DFCI TC1603099, TC1574686, TC1602602
DoTS DT.528958, DT.110941073, DT.101289690, DT.94220778, DT.91586645
NIA Mouse Gene Index U034177
EC 6.3.2.-
Consensus CDS Project CCDS26051.1
International Mouse Phenotyping Consortium Status Arel1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035485 VEGA Gene Model | MGI Sequence Detail 52753 C57BL/6J ±  kb
transcript OTTMUST00000090852 VEGA | MGI Sequence Detail 5446 Not Applicable 
polypeptide OTTMUSP00000049942 VEGA | MGI Sequence Detail 823 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(9) UniProt(9)
Polymorphisms
SNPs within 2kb(288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR000569 HECT
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198601 Kim JB, et al., Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21
All references(29)
Other
accession IDs
MGI:2144874, MGI:2145051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory