About   Help   FAQ
Ift80 Gene Detail
Summary
  • Symbol
    Ift80
  • Name
    intraflagellar transport 80
  • Synonyms
    4921524P20Rik, Wdr56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915509
    NCBI Gene: 68259
  • Gene Overview
    MyGene.info: IFT80
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68892499-69004570 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.07 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915509
protein coding gene Chr3:68892499-69004645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027290
protein coding gene Chr3:68113580-68225607 (-)
A/J MGP_AJ_G0027252
protein coding gene Chr3:66086581-66190269 (-)
AKR/J MGP_AKRJ_G0027220
protein coding gene Chr3:67498935-67607938 (-)
BALB/cJ MGP_BALBcJ_G0027263
protein coding gene Chr3:65960255-66067445 (-)
C3H/HeJ MGP_C3HHeJ_G0027007
protein coding gene Chr3:67744854-67848588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027709
protein coding gene Chr3:70650673-70776278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025062
protein coding gene Chr3:62353013-62456105 (-)
CAST/EiJ MGP_CASTEiJ_G0026454
protein coding gene Chr3:67692249-67800780 (-)
CBA/J MGP_CBAJ_G0026982
protein coding gene Chr3:72846741-72960928 (-)
DBA/2J MGP_DBA2J_G0027118
protein coding gene Chr3:65589890-65697619 (-)
FVB/NJ MGP_FVBNJ_G0027086
protein coding gene Chr3:64214858-64319395 (-)
LP/J MGP_LPJ_G0027226
protein coding gene Chr3:69051988-69162466 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027105
protein coding gene Chr3:77461096-77576524 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027767
protein coding gene Chr3:67385889-67498366 (-)
PWK/PhJ MGP_PWKPhJ_G0026188
protein coding gene Chr3:65317994-65423524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026004
protein coding gene Chr3:66491098-66603056 (-)
WSB/EiJ MGP_WSBEiJ_G0026532
protein coding gene Chr3:67524376-67654338 (-)



Homology
more
  • Human Ortholog
    IFT80, intraflagellar transport 80
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFT80, intraflagellar transport 80
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATD2, SRTD2, WDR56
  • Links
    NCBI Gene ID: 57560
    neXtProt AC: NX_Q9P2H3
    UniProt: Q9P2H3

  • Chr Location
    3q25.33; chr3:160256986-160399532 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12253
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IFT80
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Ift80 mouse models; 1 with human IFT80 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele exhibit partial perinatal lethality, decreased body size, postnatal growth retardation, shortened long bones, constricted thoracic cage, periaxial polydactyly, and small cranium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027778 Ensembl Gene Model | MGI Sequence Detail 112072 C57BL/6J ±  kb
    transcript ENSMUST00000029347 Ensembl | MGI Sequence Detail 3880 Not Applicable  
    polypeptide ENSMUSP00000029347 Ensembl | MGI Sequence Detail 777 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 6
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory