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Gpt2 Gene Detail
Summary
  • Symbol
    Gpt2
  • Name
    glutamic pyruvate transaminase (alanine aminotransferase) 2
  • Synonyms
    4631422C05Rik, ALT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915391
    NCBI Gene: 108682
Location & Maps
more
  • Sequence Map
    Chr8:85492576-85527560 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34985 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.61 cM, cytoband C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GPT2, glutamic--pyruvic transaminase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPT2, glutamic--pyruvic transaminase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALT2, GPT 2, MRT49
  • Links
    NCBI Gene ID: 84706
    neXtProt AC: NX_Q8TD30

  • Chr Location
    16q11.2; chr16:46884396-46931289 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GPT2 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 49; MRT49   OMIM: 616281
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Gpt2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023224 VEGA Gene Model | MGI Sequence Detail 34985 C57BL/6J ±  kb
transcript OTTMUST00000056213 VEGA | MGI Sequence Detail 3639 Not Applicable  
polypeptide OTTMUSP00000026985 VEGA | MGI Sequence Detail 522 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    307 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008209 alanine aminotransferase 2
  • EC
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
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  • All nucleic 115
    cDNA 114
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2138407, MGI:2142714, MGI:2142880
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 32
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory