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Tctn2
Gene Detail
 Symbol
Name
ID
Tctn2
tectonic family member 2
MGI:1915228
BioType Conflict
Synonyms 4432405B04Rik, Tect2
Feature Type protein coding gene
Genetic Map
Chromosome 5
63.68 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:124598749-124627738 bp, + strand
From VEGA annotation of GRCm38

  28990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tctn2

Human
homologs
Human Homolog TCTN2, tectonic family member 2
NCBI Gene ID 79867
neXtProt AC  NX_Q96GX1
Human Synonyms  C12orf38, MKS8, TECT2
Human Chr (Location)  12q24.31; chr12:123671113-123708403 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TCTN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit open neural tubes, exencephaly, micropthalmia, cleft palate, preaxial polydactyly, ventricular septal defect, sight-sided stomach, absent floor plate, and cilia defects.
 
Interactions
Tctn2 interacts with 93 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell projection organization, cilium assembly, ...
Component cell projection, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (156)    Tissues (41)    Images (34)
Theiler Stages: 15, 19, 23, 28
Assay TypeResults
RNA in situ 154
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024481 (Evidence)
Ensembl Gene ModelENSMUSG00000029386 (Evidence)
Entrez Gene67978 (Evidence)
DFCITC1579900, TC1595810, TC1619672, TC1620267, TC1633912
DoTSDT.110682688, DT.526942, DT.91409608, DT.94137014, DT.94242545, DT.97359842
NIA Mouse Gene IndexU006191
Consensus CDS ProjectCCDS39283.1
International Mouse Knockout Project StatusTctn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024481 VEGA Gene Model | MGI Sequence Detail 28990 C57BL/6J ±  kb
transcript OTTMUST00000060065 VEGA | MGI Sequence Detail 3400 Not Applicable 
polypeptide Q2MV57 UniProt | EBI | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011677 Domain of unknown function DUF1619
Protein Ontology PR:000016210 tectonic-2
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory