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Tctn2 Gene Detail
Summary
  • Symbol
    Tctn2
  • Name
    tectonic family member 2
  • Synonyms
    4432405B04Rik, Tect2
Location &
Maps
more
  • Sequence Map
    Chr5:124598749-124627738 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.68 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915228
protein coding gene Chr5:124598749-124627738 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015614
unclassified non-coding RNA gene Chr5:128432690-128466085 (+)
A/J MGP_AJ_G0015590
unclassified non-coding RNA gene Chr5:123075165-123104924 (+)
AKR/J MGP_AKRJ_G0015554
unclassified non-coding RNA gene Chr5:127044398-127075984 (+)
BALB/cJ MGP_BALBcJ_G0015552
unclassified non-coding RNA gene Chr5:124412741-124443610 (+)
C3H/HeJ MGP_C3HHeJ_G0015374
unclassified non-coding RNA gene Chr5:127657045-127688065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016006
unclassified non-coding RNA gene Chr5:133416558-133456374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013740
unclassified non-coding RNA gene Chr5:117610436-117630164 (+)
CAST/EiJ MGP_CASTEiJ_G0014930
unclassified non-coding RNA gene Chr5:126774698-126804944 (+)
CBA/J MGP_CBAJ_G0015355
unclassified non-coding RNA gene Chr5:138634928-138668836 (+)
DBA/2J MGP_DBA2J_G0015449
unclassified non-coding RNA gene Chr5:123093903-123124444 (+)
FVB/NJ MGP_FVBNJ_G0015456
unclassified non-coding RNA gene Chr5:122141241-122170172 (+)
LP/J MGP_LPJ_G0015530
unclassified non-coding RNA gene Chr5:128965121-128995748 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015479
unclassified non-coding RNA gene Chr5:142202499-142233889 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016048
unclassified non-coding RNA gene Chr5:126664802-126695830 (+)
PWK/PhJ MGP_PWKPhJ_G0014715
unclassified non-coding RNA gene Chr5:121918720-121949513 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014503
unclassified non-coding RNA gene Chr5:124298484-124329121 (+)
WSB/EiJ MGP_WSBEiJ_G0015034
unclassified non-coding RNA gene Chr5:127351624-127382491 (+)



Homology
more
  • Human Ortholog
    TCTN2, tectonic family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCTN2, tectonic family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C12orf38, JBTS24, MKS8, TECT2
  • Links
    NCBI Gene ID: 79867
    neXtProt AC: NX_Q96GX1
    UniProt: Q96GX1

  • Chr Location
    12q24.31; chr12:123671108-123708405 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11729
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TCTN2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human TCTN2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit open neural tubes, exencephaly, micropthalmia, cleft palate, preaxial polydactyly, ventricular septal defect, sight-sided stomach, absent floor plate, and cilia defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67978 NCBI Gene Model | MGI Sequence Detail 28990 C57BL/6J ±  kb
    transcript NM_026486 RefSeq | MGI Sequence Detail 2735 C57BL/6  
    polypeptide Q2MV57 UniProt | EBI | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR011677 Domain of unknown function DUF1619
      IPR040354 Tectonic
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:260445 Wang C, et al., Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development. 2018 Mar 15;145(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory