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Tctn2
Gene Detail
Symbol

Name
ID
Tctn2
tectonic family member 2
MGI:1915228
Synonyms
4432405B04Rik, Tect2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
63.68 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:124598749-124628771 bp, + strand
From VEGA annotation of GRCm38

  30023 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCTN2
Gene Tree: Tctn2

Human
homologs
TCTN2, tectonic family member 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79867
neXtProt AC: NX_Q96GX1

Human Synonyms: C12orf38, MKS8, TECT2

Human Chr (Location): 12q24.31; chr12:123671113-123708405 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TCTN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit open neural tubes, exencephaly, micropthalmia, cleft palate, preaxial polydactyly, ventricular septal defect, sight-sided stomach, absent floor plate, and cilia defects.
 
Interactions
Tctn2 interacts with 93 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell projection organization, cilium assembly, ...
Component cell projection, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (156)    Tissues (41)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
RT-PCR 2
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tctn2    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024481 (Evidence)
Ensembl Gene Model ENSMUSG00000029386 (Evidence)
Entrez Gene 67978 (Evidence)
DFCI TC1620267, TC1633912, TC1619672, TC1595810, TC1579900
DoTS DT.97359842, DT.91409608, DT.526942, DT.94242545, DT.94137014, DT.110682688
NIA Mouse Gene Index U006191
Consensus CDS Project CCDS39283.1
International Mouse Phenotyping Consortium Status Tctn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024481 VEGA Gene Model | MGI Sequence Detail 30023 C57BL/6J ±  kb
transcript NM_026486 RefSeq | MGI Sequence Detail 2735 C57BL/6 
polypeptide Q2MV57 UniProt | EBI | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011677 Domain of unknown function DUF1619
Protein Ontology PR:000016210 tectonic-2
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory