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Rubcn Gene Detail
Summary
  • Symbol
    Rubcn
  • Name
    RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
  • Synonyms
    1700021K19Rik, mKIAA0226
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915160
    NCBI Gene: 100502698
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32642072-32698121 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 23.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915160
 protein coding gene Chr16:32642072-32698136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022747
 protein coding gene Chr16:30939003-30993992 (-)
A/J MGP_AJ_G0022712
 protein coding gene Chr16:29459283-29509163 (-)
AKR/J MGP_AKRJ_G0022685
 protein coding gene Chr16:30525294-30571864 (-)
BALB/cJ MGP_BALBcJ_G0022714
 protein coding gene Chr16:29601491-29650396 (-)
C3H/HeJ MGP_C3HHeJ_G0022479
 protein coding gene Chr16:30646639-30695505 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023163
 protein coding gene Chr16:31601739-31654319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020681
 protein coding gene Chr16:29831440-29886211 (-)
CAST/EiJ MGP_CASTEiJ_G0022007
 protein coding gene Chr16:30792620-30852578 (-)
CBA/J MGP_CBAJ_G0022449
 protein coding gene Chr16:32873754-32928602 (-)
DBA/2J MGP_DBA2J_G0022582
 protein coding gene Chr16:29305285-29356804 (-)
FVB/NJ MGP_FVBNJ_G0022557
 protein coding gene Chr16:29291861-29341299 (-)
LP/J MGP_LPJ_G0022649
 protein coding gene Chr16:30704877-30755824 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022576
 protein coding gene Chr16:32279098-32334282 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023175
 protein coding gene Chr16:30505043-30556054 (-)
PWK/PhJ MGP_PWKPhJ_G0021746
 protein coding gene Chr16:29643421-29702554 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021577
 protein coding gene Chr16:30306438-30367433 (-)
WSB/EiJ MGP_WSBEiJ_G0022051
 protein coding gene Chr16:30470133-30525465 (-)



Homology
more
  • Human Ortholog
    RUBCN, rubicon autophagy regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RUBCN, rubicon autophagy regulator
  • Synonyms
    KIAA0226, RUBICON, SCAR15
  • Links
    NCBI Gene ID: 9711
    neXtProt AC: NX_Q92622
    UniProt: Q92622

  • Chr Location
    3q29; chr3:197668867-197749820 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rubcn mouse models; 1 with human RUBCN associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects the functioning of LAP (LC3-associated phagocytosis)-engaged phagosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    29
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100502698 NCBI Gene Model | MGI Sequence Detail 56050 C57BL/6J ±  kb
    transcript NM_001374776 RefSeq | MGI Sequence Detail 5486 C57BL/6  
    polypeptide Q80U62 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333473 Dong H, et al., Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2123247119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory