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Rubcn Gene Detail
Summary
  • Symbol
    Rubcn
  • Name
    RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
  • Synonyms
    1700021K19Rik, mKIAA0226
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915160
    NCBI Gene: 100502698
Location & Maps
more
  • Sequence Map
    Chr16:32821707-32877766 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56060 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 23.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RUBCN, RUN and cysteine rich domain containing beclin 1 interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RUBCN, RUN and cysteine rich domain containing beclin 1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0226, RUBICON, SCAR15
  • Links
    NCBI Gene ID: 9711
    neXtProt AC: NX_Q92622

  • Chr Location
    3q29; chr3:197671393-197749727 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15687
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RUBCN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RUBCN associations

Human Disease Mouse Models
       Spinocerebellar Ataxia, Autosomal Recessive 15; SCAR15   OMIM: 615705
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026856 VEGA Gene Model | MGI Sequence Detail 56060 C57BL/6J ±  kb
transcript OTTMUST00000066488 VEGA | MGI Sequence Detail 5311 Not Applicable  
polypeptide OTTMUSP00000033324 VEGA | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    413 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR025258 Putative zinc-RING and/or ribbon
    IPR004012 RUN domain
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227368 Tan X, et al., A kinase-independent role for EGF receptor in autophagy initiation. Cell. 2015 Jan 15;160(1-2):145-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory