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Prss37
Gene Detail
Symbol

Name
ID
Prss37
protease, serine 37
MGI:1914940
Synonyms
1700016G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
18.82 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:40514824-40519508 bp, - strand
From VEGA annotation of GRCm38

  4685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRSS37
Protein SuperFamily: trypsin
Gene Tree: Prss37

Human
homologs
PRSS37, protease, serine, 37
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 136242
neXtProt AC: NX_A4D1T9

Human Synonyms: TRYX2

Human Chr (Location): 7q34; chr7:141836278-141842499 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct.
 
Interactions
Prss37 interacts with 18 markers (Mir34a, Mir139, Mir140, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process binding of sperm to zona pellucida, cell migration, ...
Component extracellular region, nucleus
Function metal ion binding, serine-type endopeptidase activity
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026894 (Evidence)
Ensembl Gene Model ENSMUSG00000029909 (Evidence)
Entrez Gene 67690 (Evidence)
UniGene 52550
DFCI TC1586525
DoTS DT.60110318
NIA Mouse Gene Index U027222
Consensus CDS Project CCDS20033.1
International Mouse Phenotyping Consortium Status Prss37
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026894 VEGA Gene Model | MGI Sequence Detail 4685 C57BL/6J ±  kb
transcript OTTMUST00000066507 VEGA | MGI Sequence Detail 1049 Not Applicable 
polypeptide OTTMUSP00000033336 VEGA | MGI Sequence Detail 237 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000032454 inactive serine protease 37
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202066 Shen C, et al., Prss37 is required for male fertility in the mouse. Biol Reprod. 2013 May;88(5):123
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory