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Anp32b Gene Detail
Summary
  • Symbol
    Anp32b
  • Name
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
  • Synonyms
    2410015B15Rik, PAL31, PHAPI2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914878
    NCBI Gene: 67628
  • Gene Overview
    MyGene.info: ANP32B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:46450902-46472657 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21756 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.79 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
    Orthology source: HGNC
  • Synonyms
    APRIL, PHAPI2, SSP29
  • Links
    NCBI Gene ID: 10541
    neXtProt AC: NX_Q92688
    UniProt: Q92688

  • Chr Location
    9q22.33; chr9:97983207-98015943 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit background-sensitive partial perinatal lethality with failure to initiate breathing, craniofacial defects, enlarged brain ventricle, expanded inner ear cavities, plate closure defects, decreased body weight, premature aging, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006891 VEGA Gene Model | MGI Sequence Detail 21756 C57BL/6J ±  kb
    transcript OTTMUST00000015913 VEGA | MGI Sequence Detail 1716 Not Applicable  
    polypeptide OTTMUSP00000007314 VEGA | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      121 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004066 acidic leucine-rich nuclear phosphoprotein 32 family member B
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 171
      Genomic 1
      cDNA 169
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1926203
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
    • Latest
      J:238763 Choo HJ, et al., Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import. Stem Cells. 2016 Nov;34(11):2784-2797

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory