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Anp32b Gene Detail
Summary
  • Symbol
    Anp32b
  • Name
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
  • Synonyms
    2410015B15Rik, PAL31, PHAPI2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914878
    NCBI Gene: 67628
  • Gene Overview
    MyGene.info: ANP32B
Location & Maps
more
  • Sequence Map
    Chr4:46450902-46472657 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21756 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.79 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    ANP32B, acidic nuclear phosphoprotein 32 family member B
    Orthology source: HGNC
  • Synonyms
    APRIL, PHAPI2, SSP29
  • Links
    NCBI Gene ID: 10541
    neXtProt AC: NX_Q92688

  • Chr Location
    9q22.33; chr9:97983207-98015943 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    271
  • Gene trapped
    268
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit partial perinatal lethality associated with failure to initiate breathing, craniofacial defects, enlarged brain ventricle, expanded inner ear cavities, plaate closure defects, decreased body size and weight,premature aging, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006891 VEGA Gene Model | MGI Sequence Detail 21756 C57BL/6J ±  kb
transcript OTTMUST00000015913 VEGA | MGI Sequence Detail 1716 Not Applicable  
polypeptide OTTMUSP00000007314 VEGA | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004066 acidic leucine-rich nuclear phosphoprotein 32 family member B
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
Molecular
Reagents
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  • All nucleic 170
    cDNA 169
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1926203
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
  • Latest
    J:227403 Leo VI, et al., Balb/c-congenic ANP32B-deficient mice reveal a modifying locus that determines viability. Exp Anim. 2015 Nov 10;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory