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Pagr1a Gene Detail
Summary
  • Symbol
    Pagr1a
  • Name
    PAXIP1 associated glutamate rich protein 1A
  • Synonyms
    2900092E17Rik, C77040, PA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914528
    NCBI Gene: 67278
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127015051-127017352 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.27 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914528
protein coding gene Chr7:127015033-127017352 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033014
protein coding gene Chr7:131329225-131331544 (-)
A/J MGP_AJ_G0032997
protein coding gene Chr7:127842630-127844949 (-)
AKR/J MGP_AKRJ_G0032929
protein coding gene Chr7:131078313-131080632 (-)
BALB/cJ MGP_BALBcJ_G0033002
protein coding gene Chr7:127506052-127508371 (-)
C3H/HeJ MGP_C3HHeJ_G0032712
protein coding gene Chr7:131020777-131023096 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033508
protein coding gene Chr7:136433541-136435860 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030480
protein coding gene Chr7:129055079-129057373 (-)
CAST/EiJ MGP_CASTEiJ_G0032041
protein coding gene Chr7:122810339-122812656 (-)
CBA/J MGP_CBAJ_G0032685
protein coding gene Chr7:141021451-141023770 (-)
DBA/2J MGP_DBA2J_G0032837
protein coding gene Chr7:125816684-125819003 (-)
FVB/NJ MGP_FVBNJ_G0032790
protein coding gene Chr7:125668009-125670328 (-)
LP/J MGP_LPJ_G0032931
protein coding gene Chr7:132799800-132802119 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032822
protein coding gene Chr7:142187344-142189663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033527
protein coding gene Chr7:130094932-130097251 (-)
PWK/PhJ MGP_PWKPhJ_G0031748
protein coding gene Chr7:118813327-118815646 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031594
protein coding gene Chr7:116935695-116938049 (-)
WSB/EiJ MGP_WSBEiJ_G0032153
protein coding gene Chr7:131070571-131072890 (-)



Homology
more
  • Human Ortholog
    PAGR1, PAXIP1 associated glutamate rich protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PAGR1, PAXIP1 associated glutamate rich protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C16orf53, GAS, PA1
  • Links
    NCBI Gene ID: 79447
    neXtProt AC: NX_Q9BTK6
    UniProt: Q9BTK6

  • Chr Location
    16p11.2; chr16:29816207-29822495 (+)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to undergo axial rotation and show abnormal embryonic and extraembryonic tissue development, defects in amnion, chorion and visceral yolk sac morphology, abnormal rostral-caudal body axis extension, growth arrest, and complete embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67278 NCBI Gene Model | MGI Sequence Detail 2302 C57BL/6J ±  kb
    transcript NM_030240 RefSeq | MGI Sequence Detail 1448 Not Specified  
    polypeptide Q99L02 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2142311
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Diseases 3
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:271893 Antoine MW, et al., Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models. Neuron. 2019 Feb 20;101(4):648-661.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory