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Ndufa10 Gene Detail
Summary
  • Symbol
    Ndufa10
  • Name
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10
  • Synonyms
    2900053E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914523
    NCBI Gene: 67273
  • Gene Overview
    MyGene.info: NDUFA10
Location & Maps
more
  • Sequence Map
    Chr1:92439010-92473860 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34851 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.40 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDUFA10, NADH:ubiquinone oxidoreductase subunit A10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NDUFA10, NADH:ubiquinone oxidoreductase subunit A10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-42k, CI-42KD
  • Links
    NCBI Gene ID: 4705
    neXtProt AC: NX_O95299

  • Chr Location
    2q37.3; chr2:239957372-240025402 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFA10 associations

Human Disease Mouse Models
       Leigh Syndrome; LS   OMIM: 256000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ndufa10
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021762 VEGA Gene Model | MGI Sequence Detail 34851 C57BL/6J ±  kb
transcript OTTMUST00000051651 VEGA | MGI Sequence Detail 2020 Not Applicable  
polypeptide OTTMUSP00000024348 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    256 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011068 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
  • InterPro Domains
    IPR031314 Deoxynucleoside kinase domain
    IPR015828 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 190
    cDNA 188
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:209583 Morais VA, et al., PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014 Apr 11;344(6180):203-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory