Oxct1
Gene Detail

Symbol Name ID

Oxct1 3-oxoacid CoA transferase 1 MGI:1914291

Synonyms

2610008O03Rik, Scot-s

Feature Type

protein coding gene

Genetic Map

Chromosome 15

1.86 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:4026383-4155344 bp, + strand From VEGA annotation of GRCm38   128962 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 3-oxoacid CoA-transferase
Gene Tree: Oxct1

Human homologs

Human Homolog		OXCT1, 3-oxoacid CoA transferase 1
NCBI Gene ID		5019
neXtProt AC		NX_P55809
Human Synonyms		OXCT, SCOT
Human Chr (Location)		5p13.1; chr5:41730167-41870791 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human OXCT1

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit hyperketonemia, ketoacidosis, increased glucose oxidation in the brain, increased autophagy in the brain, and neonatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cellular ketone body metabolic process, cellular response to acid, ...
Component	mitochondrion
Function	3-oxoacid CoA-transferase activity, CoA-transferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Images (1)
Theiler Stages: 14, 15

Assay Type	Results
RT-PCR	2

cDNA source data(378)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(380) cDNA(378) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000024748 (Evidence)
Ensembl Gene Model	ENSMUSG00000022186 (Evidence)
Entrez Gene	67041 (Evidence)
UniGene	13445
DFCI	TC1573555, TC1601807
DoTS	DT.101308990, DT.496196, DT.94238757, DT.94238814, DT.94238822
EC	2.8.3.5
Consensus CDS Project	CCDS27361.1
International Mouse Knockout Project Status	Oxct1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024748	VEGA Gene Model | MGI Sequence Detail	128962	C57BL/6J
transcript	OTTMUST00000060508	VEGA | MGI Sequence Detail	3527	Not Applicable
polypeptide	OTTMUSP00000029518	VEGA | MGI Sequence Detail	520	Not Applicable

All sequences(62) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(587 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014388	3-oxoacid CoA-transferase
InterPro	IPR012792	3-oxoacid CoA-transferase, subunit A
InterPro	IPR012791	3-oxoacid CoA-transferase, subunit B
InterPro	IPR004164	Coenzyme A transferase active site
InterPro	IPR004163	Coenzyme A transferase binding site
InterPro	IPR004165	Coenzyme A transferase family I
Protein Ontology	PR:000012095	succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)