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Oxct1
Gene Detail
Symbol

Name
ID
Oxct1
3-oxoacid CoA transferase 1
MGI:1914291
Synonyms
2610008O03Rik, Scot-s
Feature Type
protein coding gene
Genetic Map
Chromosome 15
1.86 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:4026383-4155344 bp, + strand
From VEGA annotation of GRCm38

  128962 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: OXCT1
Protein SuperFamily: 3-oxoacid CoA-transferase
Gene Tree: Oxct1

Human
homologs
OXCT1, 3-oxoacid CoA transferase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5019
neXtProt AC: NX_P55809

Human Synonyms: OXCT, SCOT

Human Chr (Location): 5p13.1; chr5:41730065-41870689 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OXCT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit hyperketonemia, ketoacidosis, increased glucose oxidation in the brain, increased autophagy in the brain, and neonatal lethality.
 
Interactions
Oxct1 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(378)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase oxct1 ; ZFIN oxct1a, oxct1b    NEW 
Molecular
reagents
All nucleic(380) cDNA(378) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000024748 (Evidence)
Ensembl Gene Model ENSMUSG00000022186 (Evidence)
Entrez Gene 67041 (Evidence)
UniGene 13445
DFCI TC1601807, TC1573555
DoTS DT.94238814, DT.94238757, DT.496196, DT.101308990, DT.94238822
EC 2.8.3.5
Consensus CDS Project CCDS27361.1
International Mouse Phenotyping Consortium Status Oxct1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024748 VEGA Gene Model | MGI Sequence Detail 128962 C57BL/6J ±  kb
transcript OTTMUST00000060508 VEGA | MGI Sequence Detail 3527 Not Applicable 
polypeptide OTTMUSP00000029518 VEGA | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(609 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014388 3-oxoacid CoA-transferase
InterPro IPR012792 3-oxoacid CoA-transferase, subunit A
InterPro IPR012791 3-oxoacid CoA-transferase, subunit B
InterPro IPR004164 Coenzyme A transferase active site
InterPro IPR004163 Coenzyme A transferase binding site
InterPro IPR004165 Coenzyme A transferase family I
Protein Ontology PR:000012095 succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195934 Cotter DG, et al., Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E363-74
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory