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Rnf128 Gene Detail
Summary
  • Symbol
    Rnf128
  • Name
    ring finger protein 128
  • Synonyms
    1300002C13Rik, GRAIL, Greul1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914139
    NCBI Gene: 66889
  • Gene Overview
    MyGene.info: RNF128
Location & Maps
more
  • Sequence Map
    ChrX:139563316-139673145 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109830 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF128, ring finger protein 128, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RNF128, ring finger protein 128, E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRAIL
  • Links
    NCBI Gene ID: 79589
    neXtProt AC: NX_Q8TEB7

  • Chr Location
    Xq22.3; chrX:106693838-106797016 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a null allele dsiplay defects in naive, helper and anergic T cell states affecting survival, proliferation and cytokine secretion. Homozygotes for another null allele show impaired T cell tolerance and regulatory T cell function and increased susceptibility to autoimmune disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018735 VEGA Gene Model | MGI Sequence Detail 109830 C57BL/6J ±  kb
transcript OTTMUST00000045070 VEGA | MGI Sequence Detail 2750 Not Applicable  
polypeptide OTTMUSP00000020259 VEGA | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    240 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    cDNA 92
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147939
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory