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Rnf128
Gene Detail
Symbol

Name
ID
Rnf128
ring finger protein 128
MGI:1914139
Synonyms
1300002C13Rik, GRAIL, Greul1
Feature Type
protein coding gene
Genetic Map
Chromosome X
61.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:139563316-139673145 bp, + strand
From VEGA annotation of GRCm38

  109830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11337  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RNF128
Protein SuperFamily: ring finger protein 13
Gene Tree: Rnf128

Human
homologs
RNF128, ring finger protein 128, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 79589
neXtProt AC: NX_Q8TEB7

Human Synonyms: GRAIL

Human Chr (Location): Xq22.3; chrX:106693838-106797016 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null allele dsiplay defects in naive, helper and anergic T cell states affecting survival, proliferation and cytokine secretion. Homozygotes for another null allele show impaired T cell tolerance and regulatory T cell function and increased susceptibility to autoimmune disease.
 
Interactions
Rnf128 interacts with 250 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (167)    Tissues (161)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
Northern blot 6
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnf128    NEW 
Molecular
reagents
All nucleic(93) cDNA(92) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018735 (Evidence)
Ensembl Gene Model ENSMUSG00000031438 (Evidence)
Entrez Gene 66889 (Evidence)
UniGene 27764
DFCI TC1731905, TC1573026
DoTS DT.101707574, DT.489906, DT.111034456
NIA Mouse Gene Index U020251
EC 6.3.2.-
Consensus CDS Project CCDS30435.1, CCDS57776.1
International Mouse Phenotyping Consortium Status Rnf128
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018735 VEGA Gene Model | MGI Sequence Detail 109830 C57BL/6J ±  kb
transcript OTTMUST00000045070 VEGA | MGI Sequence Detail 2750 Not Applicable 
polypeptide OTTMUSP00000020259 VEGA | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)    SNPs within 2kb including multiple locations(252)
Protein-related
information
ResourceIDDescription
InterPro IPR003137 Protease-associated domain, PA
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014079 E3 ubiquitin-protein ligase RNF128
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209819 Aziz M, et al., Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis. J Immunol. 2014 Mar 1;192(5):2305-14
All references(47)
Other
accession IDs
MGI:2147939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory