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Spag16 Gene Detail
Summary
  • Symbol
    Spag16
  • Name
    sperm associated antigen 16
  • Synonyms
    4921511D23Rik, 4930524F24Rik, 4930585K05Rik, Pf20, Wdr29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913972
    NCBI Gene: 66722
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:69826970-70725132 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 35.04 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5759 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913972
protein coding gene Chr1:69826872-70725132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016122
protein coding gene Chr1:70208647-71128235 (+)
A/J MGP_AJ_G0016105
protein coding gene Chr1:67719210-68610546 (+)
AKR/J MGP_AKRJ_G0016062
protein coding gene Chr1:69666062-70596369 (+)
BALB/cJ MGP_BALBcJ_G0016060
protein coding gene Chr1:67823715-68729475 (+)
C3H/HeJ MGP_C3HHeJ_G0015891
protein coding gene Chr1:69990563-70918988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016513
protein coding gene Chr1:72886704-73858830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014234
protein coding gene Chr1:63472678-64344631 (+)
CAST/EiJ MGP_CASTEiJ_G0015475
protein coding gene Chr1:69212220-70159136 (+)
CBA/J MGP_CBAJ_G0015864
protein coding gene Chr1:75329852-76327005 (+)
DBA/2J MGP_DBA2J_G0015965
protein coding gene Chr1:67109780-68016445 (+)
FVB/NJ MGP_FVBNJ_G0015968
protein coding gene Chr1:66301066-67195680 (+)
LP/J MGP_LPJ_G0016037
protein coding gene Chr1:71260446-72186381 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015988
protein coding gene Chr1:78709370-79837894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016560
protein coding gene Chr1:69638256-70570795 (+)
PWK/PhJ MGP_PWKPhJ_G0015262
protein coding gene Chr1:66512117-67418564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015041
protein coding gene Chr1:69027784-69980517 (+)
WSB/EiJ MGP_WSBEiJ_G0015537
protein coding gene Chr1:69442709-70383709 (+)



Homology
more
  • Human Ortholog
    SPAG16, sperm associated antigen 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPAG16, sperm associated antigen 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PF20, WDR29
  • Links
    NCBI Gene ID: 79582
    neXtProt AC: NX_Q8N0X2
    UniProt: Q8N0X2

  • Chr Location
    2q34; chr2:213284369-214410501 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11572
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPAG16
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Chimeric males carrying one copy of the mutated allele have impaired spermatogenesis, a significant loss of germ cells at the round spermatid stage, and disorganized sperm axoneme structure. No offspring carrying the mutated allele are produced from matings using male chimeras.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053153 Ensembl Gene Model | MGI Sequence Detail 898163 C57BL/6J ±  kb
transcript ENSMUST00000065425 Ensembl | MGI Sequence Detail 2126 Not Applicable  
polypeptide ENSMUSP00000069821 Ensembl | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1922324, MGI:1923198, MGI:2138527
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory