About   Help   FAQ
Spag16 Gene Detail
Summary
  • Symbol
    Spag16
  • Name
    sperm associated antigen 16
  • Synonyms
    4921511D23Rik, 4930524F24Rik, 4930585K05Rik, Pf20, Wdr29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913972
    NCBI Gene: 66722
Location & Maps
more
  • Sequence Map
    Chr1:69826970-70725132 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      898163 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 35.04 cM, cytoband C3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SPAG16, sperm associated antigen 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPAG16, sperm associated antigen 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PF20, WDR29
  • Links
    NCBI Gene ID: 79582
    neXtProt AC: NX_Q8N0X2

  • Chr Location
    2q34; chr2:213284379-214410501 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11572
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPAG16
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Spag16
  • Incidental Mutations
Chimeric males carrying one copy of the mutated allele have impaired spermatogenesis, a significant loss of germ cells at the round spermatid stage, and disorganized sperm axoneme structure. No offspring carrying the mutated allele are produced from matings using male chimeras.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034211 VEGA Gene Model | MGI Sequence Detail 898163 C57BL/6J ±  kb
transcript OTTMUST00000086830 VEGA | MGI Sequence Detail 2126 Not Applicable  
polypeptide OTTMUSP00000047055 VEGA | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5759 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922324, MGI:1923198, MGI:2138527
References
more
  • Summaries
    All 32
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222454 Teves ME, et al., Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat. PLoS One. 2014;9(10):e107271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory