Dnase1l2
Gene Detail

Symbol Name ID

Dnase1l2 deoxyribonuclease 1-like 2 MGI:1913955

Synonyms

4733401H14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.39 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:24440081-24443105 bp, - strand From VEGA annotation of GRCm38   3025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken

Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1l2

Human homologs

Human Homolog		DNASE1L2, deoxyribonuclease I-like 2
NCBI Gene ID		1775
neXtProt AC		NX_Q92874
Human Synonyms		DNAS1L2
Human Chr (Location)		16p13.3; chr16:2286468-2288712 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruption in this gene retain DNA in corneocytes of the hair and some other structures. Hair becomes more fragile when exposed to mechanical stress.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	DNA catabolic process
Component	extracellular region
Function	deoxyribonuclease activity, endodeoxyribonuclease activity, producing 5'-phosphomonoesters, ...

External Resources: FuncBase

Expression

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000029900 (Evidence)
Ensembl Gene Model	ENSMUSG00000024136 (Evidence)
Entrez Gene	66705 (Evidence)
UniGene	29017
DFCI	TC1584369
DoTS	DT.101370742, DT.91339415
NIA Mouse Gene Index	U037525
EC	3.1.21.-
Consensus CDS Project	CCDS37489.1
International Mouse Knockout Project Status	Dnase1l2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029900	VEGA Gene Model | MGI Sequence Detail	3025	C57BL/6J
transcript	OTTMUST00000074180	VEGA | MGI Sequence Detail	1921	Not Applicable
polypeptide	OTTMUSP00000038510	VEGA | MGI Sequence Detail	278	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018057	Deoxyribonuclease I, active site
InterPro	IPR008185	Deoxyribonuclease I, eukaryotic
InterPro	IPR016202	Deoxyribonuclease I-like
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
Protein Ontology	PR:000006594	deoxyribonuclease-1-like 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180935 Fischer H, et al., Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails. J Invest Dermatol. 2011 Jun;131(6):1208-15
All references(28)