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Dnase1l2
Gene Detail
Symbol

Name
ID
Dnase1l2
deoxyribonuclease 1-like 2
MGI:1913955
Synonyms
4733401H14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.39 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:24440081-24443105 bp, - strand
From VEGA annotation of GRCm38

  3025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle

Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1l2

Human
homologs
Human Homolog DNASE1L2, deoxyribonuclease I-like 2
NCBI Gene ID 1775
neXtProt AC  NX_Q92874
Human Synonyms  DNAS1L2
Human Chr (Location)  16p13.3; chr16:2236252-2238711 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption in this gene retain DNA in corneocytes of the hair and some other structures. Mice homozygous for a different knock-out allele exhibit decreased grip strength, decreased body weight, abnormal homeostasis and abnormal skeleton.
 
Interactions
Dnase1l2 interacts with 137 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process corneocyte development, DNA catabolic process, ...
Component cytoplasm, extracellular region, ...
Function deoxyribonuclease activity, endodeoxyribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000029900 (Evidence)
Ensembl Gene ModelENSMUSG00000024136 (Evidence)
Entrez Gene66705 (Evidence)
UniGene29017
DFCITC1584369
DoTSDT.101370742, DT.91339415
NIA Mouse Gene IndexU037525
EC3.1.21.-
Consensus CDS ProjectCCDS37489.1
International Mouse Knockout Project StatusDnase1l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029900 VEGA Gene Model | MGI Sequence Detail 3025 C57BL/6J ±  kb
transcript OTTMUST00000074180 VEGA | MGI Sequence Detail 1921 Not Applicable 
polypeptide OTTMUSP00000038510 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018057 Deoxyribonuclease I, active site
InterPro IPR016202 Deoxyribonuclease I-like
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
Protein Ontology PR:000006594 deoxyribonuclease-1-like 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200082 White JK, et al., Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 2013 Jul 18;154(2):452-64
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory