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Tsfm Gene Detail
Summary
  • Symbol
    Tsfm
  • Name
    Ts translation elongation factor, mitochondrial
  • Synonyms
    2310050B20Rik, 9430024O13Rik, EF-TS, EF-Tsmt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913649
    NCBI Gene: 66399
  • Gene Overview
    MyGene.info: TSFM
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127022332-127030814 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913649
protein coding gene Chr10:127011572-127030840 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017799
protein coding gene Chr10:130583193-130605347 (-)
A/J MGP_AJ_G0017774
protein coding gene Chr10:125355626-125374866 (-)
AKR/J MGP_AKRJ_G0017737
protein coding gene Chr10:129066496-129085715 (-)
BALB/cJ MGP_BALBcJ_G0017738
protein coding gene Chr10:125762896-125782187 (-)
C3H/HeJ MGP_C3HHeJ_G0017562
protein coding gene Chr10:129196964-129218376 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018193
protein coding gene Chr10:135010044-135034325 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015873
protein coding gene Chr10:119379326-119398422 (-)
CAST/EiJ MGP_CASTEiJ_G0017122
protein coding gene Chr10:129849872-129869814 (-)
CBA/J MGP_CBAJ_G0017531
protein coding gene Chr10:140427740-140448302 (-)
DBA/2J MGP_DBA2J_G0017637
protein coding gene Chr10:124442782-124462600 (-)
FVB/NJ MGP_FVBNJ_G0017632
protein coding gene Chr10:123392944-123414002 (-)
LP/J MGP_LPJ_G0017711
protein coding gene Chr10:131154835-131174111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017660
protein coding gene Chr10:143168028-143188802 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018233
protein coding gene Chr10:129122224-129142722 (-)
PWK/PhJ MGP_PWKPhJ_G0016907
protein coding gene Chr10:124632199-124652112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016699
protein coding gene Chr10:128146222-128166760 (-)
WSB/EiJ MGP_WSBEiJ_G0017183
protein coding gene Chr10:129343264-129366323 (-)



Homology
more
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EFTS, EFTSMT
  • Links
    NCBI Gene ID: 10102
    neXtProt AC: NX_P43897
    UniProt: P43897

  • Chr Location
    12q14.1; chr12:57782745-57802856 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4184
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TSFM
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TSFM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66399 NCBI Gene Model | MGI Sequence Detail 8483 C57BL/6J ±  kb
transcript NM_025537 RefSeq | MGI Sequence Detail 1180 C57BL/6  
polypeptide Q9CZR8 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000016718 elongation factor Ts, mitochondrial
  • InterPro Domains
    IPR036402 Elongation factor Ts, dimerisation domain superfamily
    IPR001816 Translation elongation factor EFTs/EF1B
    IPR014039 Translation elongation factor EFTs/EF1B, dimerisation
    IPR018101 Translation elongation factor Ts, conserved site
    IPR009060 UBA-like superfamily
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924571
References
more
  • Summaries
    All 33
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory