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Tsfm Gene Detail
Summary
  • Symbol
    Tsfm
  • Name
    Ts translation elongation factor, mitochondrial
  • Synonyms
    2310050B20Rik, 9430024O13Rik, EF-TS, EF-Tsmt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913649
    NCBI Gene: 66399
  • Gene Overview
    MyGene.info: TSFM
Location & Maps
more
  • Sequence Map
    Chr10:127011572-127030840 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19269 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TSFM, Ts translation elongation factor, mitochondrial
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EFTS, EFTSMT
  • Links
    NCBI Gene ID: 10102
    neXtProt AC: NX_P43897

  • Chr Location
    12q14.1; chr12:57782745-57802856 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4184
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TSFM
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TSFM associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 3; COXPD3   OMIM: 610505
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    7
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030579 VEGA Gene Model | MGI Sequence Detail 19269 C57BL/6J ±  kb
transcript OTTMUST00000075721 VEGA | MGI Sequence Detail 1206 Not Applicable  
polypeptide OTTMUSP00000039756 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    218 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000016718 elongation factor Ts, mitochondrial
  • InterPro Domains
    IPR001816 Translation elongation factor EFTs/EF1B
    IPR014039 Translation elongation factor EFTs/EF1B, dimerisation
    IPR018101 Translation elongation factor Ts, conserved site
    IPR009060 UBA-like
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924571
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory