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Nfu1
Gene Detail
Symbol

Name
ID
Nfu1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
MGI:1913290
Synonyms
0610006G17Rik, CGI-33, Hirip5
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.76 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:87009236-87028461 bp, + strand
From VEGA annotation of GRCm38

  19226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFU1
Protein SuperFamily: HIRA-interacting protein 5
Gene Tree: Nfu1

Human
homologs
NFU1, NFU1 iron-sulfur cluster scaffold
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27247
neXtProt AC: NX_Q9UMS0

Human Synonyms: CGI-33, HIRIP, HIRIP5, MMDS1, Nfu, NifU, NIFUC

Human Chr (Location): 2p15-p13; chr2:69396113-69437628 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NFU1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Spontaneous(1) Targeted(2)
Genomic Mutations involving Nfu1 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nfu1 interacts with 23 markers (Mir29b-2, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process iron-sulfur cluster assembly
Component cytoplasm, cytosol, ...
Function 4 iron, 4 sulfur cluster binding, iron ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
Northern blot 12
RT-PCR 36
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfu1 ; ZFIN nfu1    NEW 
Molecular
reagents
All nucleic(80) cDNA(79) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029692 (Evidence)
Ensembl Gene Model ENSMUSG00000029993 (Evidence)
Entrez Gene 56748 (Evidence)
UniGene 23809
DFCI TC1576090
DoTS DT.110795571, DT.111129209, DT.493762, DT.97382996
NIA Mouse Gene Index U007126, U052644
PDB 1VEH
Consensus CDS Project CCDS51836.1
International Mouse Phenotyping Consortium Status Nfu1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029692 VEGA Gene Model | MGI Sequence Detail 19226 C57BL/6J ±  kb
transcript OTTMUST00000073669 VEGA | MGI Sequence Detail 1195 Not Applicable 
polypeptide OTTMUSP00000038172 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017065 HIRA-interacting protein 5
InterPro IPR001075 NIF system FeS cluster assembly, NifU, C-terminal
InterPro IPR014824 NIF system FeS cluster assembly, NifU-like scaffold, N-terminal
Protein Ontology PR:000011185 NFU1 iron-sulfur cluster scaffold, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory