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Cep41 Gene Detail
Summary
  • Symbol
    Cep41
  • Name
    centrosomal protein 41
  • Synonyms
    1700017E11Rik, 2810431D15Rik, Cep41, Tsga14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891414
    NCBI Gene: 83922
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:30653457-30693749 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40293 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.52 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CEP41, centrosomal protein 41
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP41, centrosomal protein 41
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JBTS15, TSGA14
  • Links
    NCBI Gene ID: 95681
    neXtProt AC: NX_Q9BYV8
    UniProt: Q9BYV8

  • Chr Location
    7q32.2; chr7:130393771-130441210 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10284
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CEP41
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CEP41 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes an abnormal gait, increased thermal nociceptive threshold, and alterations in fertility/fecundity and eye morphology. Some embryos homozygous for a gene trapped allele die at E10-E12 exhibiting turning failure, dilated pericardial sacs, and brain anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014400 VEGA Gene Model | MGI Sequence Detail 40293 C57BL/6J ±  kb
    transcript OTTMUST00000034104 VEGA | MGI Sequence Detail 3447 Not Applicable  
    polypeptide OTTMUSP00000015289 VEGA | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      202 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1889830, MGI:1916627, MGI:1925624, MGI:2141435
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
    • Latest
      J:182289 Ishikawa H, et al., Proteomic analysis of mammalian primary cilia. Curr Biol. 2012 Mar 6;22(5):414-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory