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Brdt
Gene Detail
Symbol

Name
ID
Brdt
bromodomain, testis-specific
MGI:1891374
Synonyms
7420412D09Rik, Brd6, Fsrg3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
52.23 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:107331159-107387058 bp, + strand
From VEGA annotation of GRCm38

  55900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Brdt

Human
homologs
Human Homolog BRDT, bromodomain, testis-specific
NCBI Gene ID 676
neXtProt AC  NX_Q58F21
Human Synonyms  BRD6, CT9
Human Chr (Location)  1p22.1; chr1:91949371-92014428 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit male infertility associated with abnormal spermatogenesis.
 
Interactions
Brdt interacts with 263 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, chromatin modification, ...
Component nucleus
Function histone binding, lysine-acetylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (176)    Tissues (163)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017134 (Evidence)
Ensembl Gene ModelENSMUSG00000029279 (Evidence)
Entrez Gene114642 (Evidence)
DFCITC1585162, TC1599214, TC1607975, TC1616836
DoTSDT.101703381, DT.524323, DT.94185901
PDB2WP1, 2WP2
Consensus CDS ProjectCCDS19500.1, CCDS39197.1
International Mouse Knockout Project StatusBrdt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017134 VEGA Gene Model | MGI Sequence Detail 55900 C57BL/6J ±  kb
transcript OTTMUST00000041477 VEGA | MGI Sequence Detail 4745 Not Applicable 
polypeptide OTTMUSP00000018624 VEGA | MGI Sequence Detail 956 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR027353 NET domain
Protein Ontology PR:000004810 bromodomain testis-specific protein
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190257 Berkovits BD, et al., The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids. Nucleic Acids Res. 2012 Aug;40(15):7162-75
All references(42)
Other
accession IDs
MGI:2442307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory