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F12
Gene Detail
Symbol

Name
ID
F12
coagulation factor XII (Hageman factor)
MGI:1891012
Synonyms
FXII
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.06 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:55417958-55426793 bp, - strand
From VEGA annotation of GRCm38

  8836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: F12
Protein SuperFamily: coagulation factor XII/hepatocyte growth factor activator
Gene Tree: F12

Human
homologs
F12, coagulation factor XII (Hageman factor)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2161
neXtProt AC: NX_P00748

Human Synonyms: HAE3, HAEX, HAF

Human Chr (Location): 5q35.3; chr5:177402138-177416524 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human F12

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving F12 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are protected from ischemic brain injury in an experimental stroke model, without exhibiting an increase in infarct-associated hemorrhage.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
F12 interacts with 19 markers (Mir136, Mir137, Mir199a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process blood coagulation, Factor XII activation, ...
Component extracellular exosome, extracellular region, ...
Function hydrolase activity, peptidase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (64)    Tissues (14)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 16
cDNA source data(49)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase f12    NEW 
Molecular
reagents
All nucleic(51) cDNA(49) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035495 (Evidence)
Ensembl Gene Model ENSMUSG00000021492 (Evidence)
Entrez Gene 58992 (Evidence)
UniGene 42224
DFCI TC1582096
DoTS DT.532017, DT.94192644
NIA Mouse Gene Index U034815
EC 3.4.21.38
Consensus CDS Project CCDS36675.1
International Mouse Phenotyping Consortium Status F12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035495 VEGA Gene Model | MGI Sequence Detail 8836 C57BL/6J ±  kb
transcript OTTMUST00000090888 VEGA | MGI Sequence Detail 1960 Not Applicable 
polypeptide OTTMUSP00000049979 VEGA | MGI Sequence Detail 597 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000083 Fibronectin, type I
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007296 coagulation factor XII
References
(Earliest) J:74089 Ong K, et al., Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
(Latest) J:209398 Matafonov A, et al., Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood. 2014 Mar 13;123(11):1739-46
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory