F12
Gene Detail

Symbol Name ID

F12 coagulation factor XII (Hageman factor) MGI:1891012

Synonyms

FXII

Feature Type

protein coding gene

Genetic Map

Chromosome 13

30.06 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:55417958-55426793 bp, - strand From VEGA annotation of GRCm38   8836 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: coagulation factor XII/hepatocyte growth factor activator
Gene Tree: F12

Human homologs

Human Homolog		F12, coagulation factor XII (Hageman factor)
NCBI Gene ID		2161
neXtProt AC		NX_P00748
Human Synonyms		HAE3, HAEX, HAF
Human Chr (Location)		5q33-qter; chr5:176829139-176836577 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human F12

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a knock-out allele are protected from ischemic brain injury in an experimental stroke model, without exhibiting an increase in infarct-associated hemorrhage.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	blood coagulation, Factor XII activation, ...
Component	extracellular region, extracellular space
Function	catalytic activity, hydrolase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (64)    Tissues (14)    Images (48)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	48
RT-PCR	16

cDNA source data(48)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(48) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035495 (Evidence)
Ensembl Gene Model	ENSMUSG00000021492 (Evidence)
Entrez Gene	58992 (Evidence)
UniGene	42224
DFCI	TC1582096
DoTS	DT.532017, DT.94192644
NIA Mouse Gene Index	U034815
EC	3.4.21.38
Consensus CDS Project	CCDS36675.1
International Mouse Knockout Project Status	F12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035495	VEGA Gene Model | MGI Sequence Detail	8836	C57BL/6J
transcript	OTTMUST00000090888	VEGA | MGI Sequence Detail	1960	Not Applicable
polypeptide	OTTMUSP00000049979	VEGA | MGI Sequence Detail	597	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014394	Coagulation factor XIIa/hepatocyte growth factor activator
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000083	Fibronectin, type I
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000007296	coagulation factor XII

References

(Earliest) J:74089 Ong K, et al., Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
(Latest) J:191325 Darbousset R, et al., Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012 Sep 6;120(10):2133-43
All references(37)