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Wasf1
Gene Detail
 Symbol
Name
ID
Wasf1
WAS protein family, member 1
MGI:1890563
Synonyms Scar, WAVE, WAVE-1
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:40883475-40938570 bp, + strand
From VEGA annotation of GRCm38

  55096 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf1

Human
homologs
Human Homolog WASF1, WAS protein family, member 1
NCBI Gene ID 8936
neXtProt AC  NX_Q92558
Human Synonyms  SCAR1, WAVE, WAVE1
Human Chr (Location)  6q21; chr6:110099819-110180016 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(59) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this gene has been associated with both morphological and functional defects of the central nervous system. Targeted mutagenesis has resulted in mice that display sensorimotor and cognitive defects similar to those exhibited by patients with 3p-syndrome mental retardation.
 
Interactions
Wasf1 interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process actin cytoskeleton organization, lamellipodium morphogenesis, ...
Component cell junction, cytoplasm, ...
Function actin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (76)    Tissues (24)    Images (22)
Theiler Stages: 10, 15, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 62
RT-PCR 12
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020871 (Evidence)
Ensembl Gene ModelENSMUSG00000019831 (Evidence)
Entrez Gene83767 (Evidence)
UniGene41353
DFCITC1580088
DoTSDT.55234412, DT.60104105
NIA Mouse Gene IndexU011428
Consensus CDS ProjectCCDS23801.1
International Mouse Knockout Project StatusWasf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020871 VEGA Gene Model | MGI Sequence Detail 55096 C57BL/6J ±  kb
transcript OTTMUST00000049339 VEGA | MGI Sequence Detail 2609 Not Applicable 
polypeptide OTTMUSP00000022835 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017372 Wiskott-Aldrich syndrome protein family member 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:206834 Chen B, et al., The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell. 2014 Jan 16;156(1-2):195-207
All references(60)
Other
accession IDs
MGI:2143538, MGI:2143675

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory