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Rnase2a Gene Detail
Summary
  • Symbol
    Rnase2a
  • Name
    ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin)
  • Synonyms
    Ear11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890465
    NCBI Gene: 93726
  • Gene Overview
    MyGene.info: RNASE2
Location & Maps
more
  • Sequence Map
    Chr14:51255266-51256112 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      847 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 26.44 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
    Orthology source: HomoloGene
  • Synonyms
    EDN, RAF3, RNS2
  • Links
    NCBI Gene ID: 6036
    neXtProt AC: NX_P10153

  • Chr Location
    14q11.2; chr14:20955471-20956435 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Rnase2a
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047222 Ensembl Gene Model | MGI Sequence Detail 847 C57BL/6J ±  kb
transcript ENSMUST00000061936 Ensembl | MGI Sequence Detail 686 Not Applicable  
polypeptide ENSMUSP00000056418 Ensembl | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001427 Pancreatic ribonuclease
    IPR023411 Ribonuclease A, active site
    IPR023412 Ribonuclease A-domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 18
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:69087 Cormier SA, et al., Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome. 2001 May;12(5):352-61
  • Latest
    J:220535 Yamada KJ, et al., Eosinophil-associated Ribonuclease 11 Is a Macrophage Chemoattractant. J Biol Chem. 2015 Apr 3;290(14):8863-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory