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Adar
Gene Detail
Symbol

Name
ID
Adar
adenosine deaminase, RNA-specific
MGI:1889575
Synonyms
ADAR1, Adar1p110, Adar1p150, mZaADAR
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.19 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:89715022-89753446 bp, + strand
From VEGA annotation of GRCm38

  38425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: double-stranded RNA-specific adenosine deaminase
Gene Tree: Adar

Human
homologs
Human Homolog ADAR, adenosine deaminase, RNA-specific
NCBI Gene ID 103
neXtProt AC  NX_P55265
Human Synonyms  ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI4, IFI-4, K88DSRBP, P136
Human Chr (Location)  1q21.3; chr1:154582057-154627999 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ADAR
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(25) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die during gestation. Inactivation of this locus has been associated with increased apoptosis and, in some lines, defects in both primitive and definitive hematopoiesis.
 
Phenotype Images(2)
Interactions
Adar interacts with 266 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process adenosine to inosine editing, base conversion or substitution editing, ...
Component cytoplasm, membrane, ...
Function adenosine deaminase activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (209)    Tissues (163)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 201
RT-PCR 2
cDNA source data(160)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(164) Genomic(1) cDNA(161) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020280 (Evidence)
Ensembl Gene ModelENSMUSG00000027951 (Evidence)
Entrez Gene56417 (Evidence)
UniGene316628
DFCITC1584283, TC1574591
DoTSDT.101397482, DT.101397485, DT.91578161, DT.97409471, DT.494187
NIA Mouse Gene IndexU042455
EC3.5.4.37
Consensus CDS ProjectCCDS17513.1, CCDS17514.1, CCDS50963.1
International Mouse Knockout Project StatusAdar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020280 VEGA Gene Model | MGI Sequence Detail 38425 C57BL/6J ±  kb
transcript OTTMUST00000048132 VEGA | MGI Sequence Detail 5871 Not Applicable 
polypeptide OTTMUSP00000021977 VEGA | MGI Sequence Detail 1178 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(12) UniProt(13)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002466 Adenosine deaminase/editase
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000003745 double-stranded RNA-specific adenosine deaminase
References
(Earliest) J:64308 Weier HU, et al., Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet. 2000;89(3-4):214-5
(Latest) J:200651 Garcia-Lopez J, et al., Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos. Nucleic Acids Res. 2013 May 1;41(10):5483-93
All references(60)
Other
accession IDs
MGI:2139942

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory