About   Help   FAQ
Atp2c1
Gene Detail
Symbol

Name
ID
Atp2c1
ATPase, Ca++-sequestering
MGI:1889008
Synonyms
1700121J11Rik, ATP2C1A, D930003G21Rik, MGC:58010, PMR1, SPCA
Feature Type
protein coding gene
Genetic Map
Chromosome 9
56.61 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:105403539-105527319 bp, - strand
From VEGA annotation of GRCm38

  123781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP2C1
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2c1

Human
homologs
ATP2C1, ATPase, Ca++ transporting, type 2C, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27032
neXtProt AC: NX_P98194

Human Synonyms: ATP2C1A, BCPM, HHD, hSPCA1, PMR1, SPCA1

Human Chr (Location): 3q22.1; chr3:130850483-131016712 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ATP2C1

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show embryonic growth retardation, failure of rostral neural tube closure, Golgi and endoplasmic reticulum stress, increased apoptosis, accumulation of intracellular lipid droplets and midgestational lethality. Aged heterozygotes develop squamous cell tumors.
 
Phenotype Images(4)
Interactions
Atp2c1 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (9)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 14
Western blot 6
RT-PCR 10
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp2c1    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(15) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000042223 (Evidence)
Ensembl Gene Model ENSMUSG00000032570 (Evidence)
Entrez Gene 235574 (Evidence)
DFCI TC1576126, TC1595139, TC1672127, TC1599560, TC1599077
DoTS DT.110588159, DT.40137532, DT.101123444, DT.101398407, DT.94236083, DT.91364165, DT.40162118, DT.97346876
NIA Mouse Gene Index U031277
EC 3.6.3.8
Consensus CDS Project CCDS40752.1, CCDS57697.1, CCDS57698.1
International Mouse Phenotyping Consortium Status Atp2c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042223 VEGA Gene Model | MGI Sequence Detail 123781 C57BL/6J ±  kb
transcript OTTMUST00000110891 VEGA | MGI Sequence Detail 4665 Not Applicable 
polypeptide OTTMUSP00000061947 VEGA | MGI Sequence Detail 952 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(16) UniProt(16)
Polymorphisms
SNPs within 2kb(1257 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1261)
Protein-related
information
ResourceIDDescription
InterPro IPR006413 Calcium-transporting P-type ATPase, subfamily IIA, PMR1-type
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004449 calcium-transporting ATPase type 2C member 1
References
(Earliest) J:64183 Shull GE, Gene knockout studies of Ca2+-transporting ATPases. Eur J Biochem. 2000 Sep;267(17):5284-90
(Latest) J:194388 Shull GE, et al., Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction. Biofactors. 2011 May-Jun;37(3):150-8
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1923888, MGI:2143288, MGI:2444235

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory