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Atp2c1
Gene Detail
Symbol

Name
ID
Atp2c1
ATPase, Ca++-sequestering
MGI:1889008
Synonyms
1700121J11Rik, ATP2C1A, D930003G21Rik, MGC:58010, PMR1, SPCA
Feature Type
protein coding gene
Genetic Map
Chromosome 9
56.61 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:105403539-105527319 bp, - strand
From VEGA annotation of GRCm38

  123781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2c1

Human
homologs
Human Homolog ATP2C1, ATPase, Ca++ transporting, type 2C, member 1
NCBI Gene ID 27032
neXtProt AC  NX_P98194
Human Synonyms  ATP2C1A, BCPM, HHD, hSPCA1, PMR1, SPCA1
Human Chr (Location)  3q22.1; chr3:130850483-131016712 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATP2C1
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show embryonic growth retardation, failure of rostral neural tube closure, Golgi and endoplasmic reticulum stress, increased apoptosis, accumulation of intracellular lipid droplets and midgestational lethality. Aged heterozygotes develop squamous cell tumors.
 
Phenotype Images(4)
Interactions
Atp2c1 interacts with 299 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process actin cytoskeleton reorganization, ATP catabolic process, ...
Component Golgi apparatus, Golgi membrane, ...
Function ATP binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (9)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 14
Western blot 6
RT-PCR 10
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(15) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000042223 (Evidence)
Ensembl Gene ModelENSMUSG00000032570 (Evidence)
Entrez Gene235574 (Evidence)
DFCITC1576126, TC1595139, TC1599077, TC1599560, TC1672127
DoTSDT.101123444, DT.101398407, DT.110588159, DT.40137532, DT.40162118, DT.91364165, DT.94236083, DT.97346876
NIA Mouse Gene IndexU031277
EC3.6.3.8
Consensus CDS ProjectCCDS40752.1, CCDS57697.1, CCDS57698.1
International Mouse Knockout Project StatusAtp2c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042223 VEGA Gene Model | MGI Sequence Detail 123781 C57BL/6J ±  kb
transcript OTTMUST00000110891 VEGA | MGI Sequence Detail 4665 Not Applicable 
polypeptide OTTMUSP00000061947 VEGA | MGI Sequence Detail 952 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(18) UniProt(16)
Polymorphisms
SNPs within 2kb(1257 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1261)
Protein-related
information
ResourceIDDescription
InterPro IPR006413 Calcium-transporting P-type ATPase, subfamily IIA, PMR1-type
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004449 calcium-transporting ATPase type 2C member 1
References
(Earliest) J:64183 Shull GE, Gene knockout studies of Ca2+-transporting ATPases. Eur J Biochem. 2000 Sep;267(17):5284-90
(Latest) J:194388 Shull GE, et al., Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction. Biofactors. 2011 May-Jun;37(3):150-8
All references(44)
Other
accession IDs
MGI:1923888, MGI:2143288, MGI:2444235

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory