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Atp2c1 Gene Detail
Summary
  • Symbol
    Atp2c1
  • Name
    ATPase, Ca++-sequestering
  • Synonyms
    1700121J11Rik, ATP2C1A, D930003G21Rik, MGC:58010, PMR1, SPCA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889008
    NCBI Gene: 235574
  • Gene Overview
    MyGene.info: ATP2C1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:105411362-105521257 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 56.61 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889008
protein coding gene Chr9:105403539-105527319 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035215
protein coding gene Chr9:107138377-107263077 (-)
A/J MGP_AJ_G0035195
protein coding gene Chr9:103265702-103386074 (-)
AKR/J MGP_AKRJ_G0035127
protein coding gene Chr9:105854913-105983632 (-)
BALB/cJ MGP_BALBcJ_G0035188
protein coding gene Chr9:102969569-103091188 (-)
C3H/HeJ MGP_C3HHeJ_G0034898
protein coding gene Chr9:106254866-106382234 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035708
protein coding gene Chr9:110096013-110231549 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032606
protein coding gene Chr9:100793897-100917316 (-)
CAST/EiJ MGP_CASTEiJ_G0034210
protein coding gene Chr9:106135415-106275485 (-)
CBA/J MGP_CBAJ_G0034867
protein coding gene Chr9:113933825-114058871 (-)
DBA/2J MGP_DBA2J_G0035028
protein coding gene Chr9:102751668-102872980 (-)
FVB/NJ MGP_FVBNJ_G0034976
protein coding gene Chr9:101527635-101644310 (-)
LP/J MGP_LPJ_G0035104
protein coding gene Chr9:107351761-107478306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035015
protein coding gene Chr9:115642094-115773329 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035730
protein coding gene Chr9:106096345-106219349 (-)
PWK/PhJ MGP_PWKPhJ_G0033917
protein coding gene Chr9:103039213-103164830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033752
protein coding gene Chr9:106155073-106282312 (-)
WSB/EiJ MGP_WSBEiJ_G0034330
protein coding gene Chr9:105968176-106106473 (-)



Homology
more
  • Human Ortholog
    ATP2C1, ATPase secretory pathway Ca2+ transporting 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP2C1, ATPase secretory pathway Ca2+ transporting 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATP2C1A, BCPM, HHD, hSPCA1, PMR1, SPCA1
  • Links
    NCBI Gene ID: 27032
    neXtProt AC: NX_P98194
    UniProt: P98194

  • Chr Location
    3q22.1; chr3:130850500-131016712 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ATP2C1 associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation, failure of rostral neural tube closure, Golgi and endoplasmic reticulum stress, increased apoptosis, accumulation of intracellular lipid droplets and midgestational lethality. Agedheterozygotes develop squamous cell tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 235574 NCBI Gene Model | MGI Sequence Detail 109896 C57BL/6J ±  kb
    transcript NM_001359822 RefSeq | MGI Sequence Detail 4901 C57BL/6  
    polypeptide Q80XR2 UniProt | EBI | MGI Sequence Detail 918 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • EC
    • InterPro Domains
      IPR030336 Calcium-transporting ATPase type 2C member 1
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR018303 P-type ATPase, phosphorylation site
      IPR006413 P-type ATPase, subfamily IIA, PMR1-type
      IPR023298 P-type ATPase, transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 15
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923888, MGI:2143288, MGI:2444235
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:64183 Shull GE, Gene knockout studies of Ca2+-transporting ATPases. Eur J Biochem. 2000 Sep;267(17):5284-90
    • Latest
      J:266546 Brown JM, et al., Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development. 2018 Oct 5;145(19)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory