Fzd2
Gene Detail

Symbol Name ID

Fzd2 frizzled homolog 2 (Drosophila) MGI:1888513

Synonyms

Fz10, Mfz10, Mfz10a

Feature Type

protein coding gene

Genetic Map

Chromosome 11

66.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:102604396-102608058 bp, + strand From VEGA annotation of GRCm38   3663 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd2

Human homologs

Human Homolog		FZD2, frizzled family receptor 2
NCBI Gene ID		2535
neXtProt AC		NX_Q14332
Human Synonyms		fz-2, Fz2, fzE2, hFz2
Human Chr (Location)		17q21.1; chr17:42634812-42638630 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

About 50% of mice homozygous for a reporter allele display a cleft palate and die as neonates; the remaining 50% survive exhibiting a variable degree of postnatal runting and reduced olfactory sensitivity to various odorants.

 

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	axonogenesis, brain development, ...
Component	apical part of cell, cytoplasm, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (40 records)
Data Summary: Results (310)    Tissues (176)    Images (37)
Theiler Stages: 1, 2, 3, 4, 5, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	249
RT-PCR	61

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(12) Primer pair(6)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000002949 (Evidence)
Ensembl Gene Model	ENSMUSG00000050288 (Evidence)
Entrez Gene	57265 (Evidence)
DFCI	TC1582930, TC1638294, TC1684067
DoTS	DT.101296330, DT.524904
NIA Mouse Gene Index	U013394
Consensus CDS Project	CCDS25501.1
International Mouse Knockout Project Status	Fzd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002949	VEGA Gene Model | MGI Sequence Detail	3663	C57BL/6J
transcript	OTTMUST00000006054	VEGA | MGI Sequence Detail	3663	Not Applicable
polypeptide	OTTMUSP00000002857	VEGA | MGI Sequence Detail	570	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026550	Frizzled-2
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007719	frizzled-2

References

(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:189062 Yu H, et al., Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development. 2012 Dec;139(23):4383-94
All references(80)

Other accession IDs

MGI:2144531