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Dynll1 Gene Detail
Summary
  • Symbol
    Dynll1
  • Name
    dynein light chain LC8-type 1
  • Synonyms
    8kDa LC, DLC8, Dnclc1, Pin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861457
    NCBI Gene: 56455
  • Gene Overview
    MyGene.info: DYNLL1
Location & Maps
more
  • Sequence Map
    Chr5:115297110-115300999 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3890 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.04 cM, cytoband F
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DYNLL1, dynein light chain LC8-type 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DYNLL1, dynein light chain LC8-type 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DLC1, DLC8, DNCL1, DNCLC1, hdlc1, LC8, LC8a, PIN
  • Links
    NCBI Gene ID: 8655
    neXtProt AC: NX_P63167

  • Chr Location
    12q24.23; chr12:120469857-120498495 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    42
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dynll1
  • Incidental Mutations
Mice carrying a knock-out mutation of this gene exhibit preweaning lethality. Mice homozygous for a gene trap allele exhibit heterotaxia, small or absent lungs and abnormal cilia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014648 VEGA Gene Model | MGI Sequence Detail 3890 C57BL/6J ±  kb
transcript OTTMUST00000034743 VEGA | MGI Sequence Detail 2030 Not Applicable  
polypeptide OTTMUSP00000015546 VEGA | MGI Sequence Detail 89 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002325 dynein light chain 1, cytoplasmic
  • InterPro Domains
    IPR001372 Dynein light chain, type 1/2
    IPR019763 Dynein light chain, type 1/2, conserved site
Molecular
Reagents
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  • All nucleic 273
    cDNA 271
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 58
    Developmental Gene Expression 8
    Gene Ontology 13
    Phenotypes 17
  • Earliest
    J:76982 King SM, et al., Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J Biol Chem. 1996 Aug 9;271(32):19358-66
  • Latest
    J:230105 Wong DM, et al., The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. Cell Rep. 2016 Feb 16;14(6):1488-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory