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Dynll1
Gene Detail
Symbol

Name
ID
Dynll1
dynein light chain LC8-type 1
MGI:1861457
Synonyms
8kDa LC, DLC8, Dnclc1, Pin
Feature Type
protein coding gene
Genetic Map
Chromosome 5
56.04 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:115297110-115300999 bp, - strand
From VEGA annotation of GRCm38

  3890 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: DYNLL1
Protein SuperFamily: dynein light chain
Gene Tree: Dynll1

Human
homologs
DYNLL1, dynein, light chain, LC8-type 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8655
neXtProt AC: NX_P63167

Human Synonyms: DLC1, DLC8, DNCL1, DNCLC1, hdlc1, LC8, LC8a, PIN

Human Chr (Location): 12q24.23; chr12:120469857-120498495 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(42) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying a knock-out mutation of this gene exhibit preweaning lethality. Mice homozygous for a gene trap allele exhibit heterotaxia, small or absent lungs and abnormal cilia.
 
Interactions
Dynll1 interacts with 180 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process apoptotic process, cilium morphogenesis, ...
Component cell, centrosome, ...
Function enzyme binding, enzyme inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (35)    Tissues (34)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 7
cDNA source data(270)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dynll1 ; ZFIN dynll1    NEW 
Molecular
reagents
All nucleic(273) cDNA(271) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000014648 (Evidence)
Ensembl Gene Model ENSMUSG00000009013 (Evidence)
Entrez Gene 56455 (Evidence)
UniGene 256858
DFCI TC1662601, TC1573411
DoTS DT.110639266, DT.101361839, DT.101277323, DT.99868905, DT.87073120
NIA Mouse Gene Index U026627, U100564
Consensus CDS Project CCDS39227.1
International Mouse Phenotyping Consortium Status Dynll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014648 VEGA Gene Model | MGI Sequence Detail 3890 C57BL/6J ±  kb
transcript OTTMUST00000034743 VEGA | MGI Sequence Detail 2030 Not Applicable 
polypeptide OTTMUSP00000015546 VEGA | MGI Sequence Detail 89 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001372 Dynein light chain, type 1/2
InterPro IPR019763 Dynein light chain, type 1/2, conserved site
Protein Ontology PR:000002325 dynein light chain 1, cytoplasmic
References
(Earliest) J:76982 King SM, et al., Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J Biol Chem. 1996 Aug 9;271(32):19358-66
(Latest) J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory