Dynll1
Gene Detail

Symbol Name ID

Dynll1 dynein light chain LC8-type 1 MGI:1861457

Synonyms

8kDa LC, DLC8, Dnclc1, Pin

Feature Type

protein coding gene

Genetic Map

Chromosome 5

56.04 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:115297110-115300999 bp, - strand From VEGA annotation of GRCm38   3890 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 1 dog

Protein SuperFamily: dynein light chain
Gene Tree: Dynll1

Human homologs

Human Homolog		DYNLL1, dynein, light chain, LC8-type 1
NCBI Gene ID		8655
neXtProt AC		NX_P63167
Human Synonyms		DLC1, DLC8, DNCL1, DNCLC1, hdlc1, LC8, LC8a, PIN
Human Chr (Location)		12q24.23; chr12:120907660-120936298 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(44) : Targeted(2) Gene trapped(42)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	apoptotic process, microtubule-based movement, ...
Component	centrosome, cytoplasm, ...
Function	enzyme binding, enzyme inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (38)    Tissues (38)    Images (8)
Theiler Stages: 2, 3, 4, 5, 19, 23, 28

Assay Type	Results
RNA in situ	28
RT-PCR	10

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000014648 (Evidence)
Ensembl Gene Model	ENSMUSG00000009013 (Evidence)
Entrez Gene	56455 (Evidence)
DFCI	TC1573411, TC1662601
DoTS	DT.101277323, DT.101361839, DT.110639266, DT.87073120, DT.99868905
Consensus CDS Project	CCDS39227.1
International Mouse Knockout Project Status	Dynll1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014648	VEGA Gene Model | MGI Sequence Detail	3890	C57BL/6J
transcript	OTTMUST00000034745	VEGA | MGI Sequence Detail	729	Not Applicable
polypeptide	OTTMUSP00000015547	VEGA | MGI Sequence Detail	89	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001372	Dynein light chain, type 1/2
InterPro	IPR019763	Dynein light chain, type 1/2, conserved site
Protein Ontology	PR:000002325	dynein light chain 1, cytoplasmic

References

(Earliest) J:76982 King SM, et al., Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J Biol Chem. 1996 Aug 9;271(32):19358-66
(Latest) J:191832 Jurado S, et al., The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. J Exp Med. 2012 Aug 27;209(9):1629-39
All references(54)