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Dynll1
Gene Detail
Symbol

Name
ID
Dynll1
dynein light chain LC8-type 1
MGI:1861457
Synonyms
8kDa LC, DLC8, Dnclc1, Pin
Feature Type
protein coding gene
Genetic Map
Chromosome 5
56.04 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:115297110-115300999 bp, - strand
From VEGA annotation of GRCm38

  3890 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: dynein light chain
Gene Tree: Dynll1

Human
homologs
Human Homolog DYNLL1, dynein, light chain, LC8-type 1
NCBI Gene ID 8655
neXtProt AC  NX_P63167
Human Synonyms  DLC1, DLC8, DNCL1, DNCLC1, hdlc1, LC8, LC8a, PIN
Human Chr (Location)  12q24.23; chr12:120469857-120498495 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(42) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying a knock-out mutation of this gene exhibit preweaning lethality.
 
Interactions
Dynll1 interacts with 180 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apoptotic process, microtubule-based movement, ...
Component centrosome, COP9 signalosome, ...
Function enzyme binding, enzyme inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (33)    Tissues (33)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 5
cDNA source data(270)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(272) cDNA(271) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000014648 (Evidence)
Ensembl Gene ModelENSMUSG00000009013 (Evidence)
Entrez Gene56455 (Evidence)
UniGene256858
DFCITC1662601, TC1573411
DoTSDT.87073120, DT.99868905, DT.101361839, DT.110639266, DT.101277323
Consensus CDS ProjectCCDS39227.1
International Mouse Knockout Project StatusDynll1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014648 VEGA Gene Model | MGI Sequence Detail 3890 C57BL/6J ±  kb
transcript OTTMUST00000034743 VEGA | MGI Sequence Detail 2030 Not Applicable 
polypeptide OTTMUSP00000015546 VEGA | MGI Sequence Detail 89 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001372 Dynein light chain, type 1/2
InterPro IPR019763 Dynein light chain, type 1/2, conserved site
Protein Ontology PR:000002325 dynein light chain 1, cytoplasmic
References
(Earliest) J:76982 King SM, et al., Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J Biol Chem. 1996 Aug 9;271(32):19358-66
(Latest) J:211696 Goggolidou P, et al., Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014 May 22;
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory