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Tdp2 Gene Detail
Summary
  • Symbol
    Tdp2
  • Name
    tyrosyl-DNA phosphodiesterase 2
  • Synonyms
    D13Ertd656e, Ttrap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860486
    NCBI Gene: 56196
  • Gene Overview
    MyGene.info: TDP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:24831679-24842153 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860486
protein coding gene Chr13:24831659-24842153 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020382
protein coding gene Chr13:22322221-22341339 (+)
A/J MGP_AJ_G0020331
protein coding gene Chr13:21917316-21927994 (+)
AKR/J MGP_AKRJ_G0020311
protein coding gene Chr13:22157307-22169269 (+)
BALB/cJ MGP_BALBcJ_G0020329
protein coding gene Chr13:21893557-21904865 (+)
C3H/HeJ MGP_C3HHeJ_G0020133
protein coding gene Chr13:22238887-22250831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020766
protein coding gene Chr13:23123183-23135834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018354
protein coding gene Chr13:20631018-20640214 (+)
CAST/EiJ MGP_CASTEiJ_G0019650
protein coding gene Chr13:21944859-21957803 (+)
CBA/J MGP_CBAJ_G0020087
protein coding gene Chr13:24010020-24022226 (+)
DBA/2J MGP_DBA2J_G0020213
protein coding gene Chr13:21411469-21423233 (+)
FVB/NJ MGP_FVBNJ_G0020197
protein coding gene Chr13:21058020-21070372 (+)
LP/J MGP_LPJ_G0020286
protein coding gene Chr13:22628149-22640596 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020224
protein coding gene Chr13:24263812-24276845 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020808
protein coding gene Chr13:22003360-22013880 (+)
PWK/PhJ MGP_PWKPhJ_G0019404
protein coding gene Chr13:21434790-21445873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019220
protein coding gene Chr13:20828909-20842916 (+)
WSB/EiJ MGP_WSBEiJ_G0019710
protein coding gene Chr13:22171571-22183586 (+)



Homology
more
  • Human Ortholog
    TDP2, tyrosyl-DNA phosphodiesterase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TDP2, tyrosyl-DNA phosphodiesterase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD022, dJ30M3.3, EAP2, EAPII, hTDP2, TTRAP
  • Links
    NCBI Gene ID: 51567
    neXtProt AC: NX_O95551
    UniProt: O95551

  • Chr Location
    6p22.3; chr6:24649977-24666887 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9591
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TDP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice carrying a gene trap insertion into intron 5 but subsequently shown to harbor a partial duplication of the wild-type allele at the ES cell level are born with a normal Mendelian distribution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035958 Ensembl Gene Model | MGI Sequence Detail 10475 C57BL/6J ±  kb
    transcript ENSMUST00000038039 Ensembl | MGI Sequence Detail 1957 Not Applicable  
    polypeptide ENSMUSP00000035660 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 1
      cDNA 68
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289161
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:246739 Schellenberg MJ, et al., Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res. 2016 May 05;44(8):3829-44

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory