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Tdp2 Gene Detail
Summary
  • Symbol
    Tdp2
  • Name
    tyrosyl-DNA phosphodiesterase 2
  • Synonyms
    D13Ertd656e, Ttrap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860486
    NCBI Gene: 56196
  • Gene Overview
    MyGene.info: TDP2
Location & Maps
more
  • Sequence Map
    Chr13:24831679-24842153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10475 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TDP2, tyrosyl-DNA phosphodiesterase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TDP2, tyrosyl-DNA phosphodiesterase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AD022, dJ30M3.3, EAP2, EAPII, hTDP2, TTRAP
  • Links
    NCBI Gene ID: 51567
    neXtProt AC: NX_O95551

  • Chr Location
    6p22.3-p22.1; chr6:24649977-24666989 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9591
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TDP2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TDP2 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia, Autosomal Recessive 23; SCAR23   OMIM: 616949
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Tdp2
  • Incidental Mutations
Homozygous mutant mice carrying a gene trap insertion into intron 5 but subsequently shown to harbor a partial duplication of the wild-type allele at the ES cell level are born with a normal Mendelian distribution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000605 VEGA Gene Model | MGI Sequence Detail 10475 C57BL/6J ±  kb
transcript OTTMUST00000001202 VEGA | MGI Sequence Detail 1957 Not Applicable  
polypeptide OTTMUSP00000000562 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 69
    Genomic 1
    cDNA 67
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1289161
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:195301 Gomez-Herreros F, et al., TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet. 2013 Mar;9(3):e1003226

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory