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Psmg1
Gene Detail
 Symbol
Name
ID
Psmg1
proteasome (prosome, macropain) assembly chaperone 1
MGI:1860263
Synonyms Dscr2
Feature Type protein coding gene
Genetic Map
Chromosome 16
56.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:95979933-95990960 bp, - strand
From VEGA annotation of GRCm38

  11028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: proteasome assembling chaperone-1
Gene Tree: Psmg1

Human
homologs
Human Homolog PSMG1, proteasome (prosome, macropain) assembly chaperone 1
NCBI Gene ID 8624
neXtProt AC  NX_O95456
Human Synonyms  C21LRP, DSCR2, LRPC21, PAC1, PAC-1
Human Chr (Location)  21q22.3; chr21:39175446-39183514 (-)  GRCh38
Alleles
and
phenotypes
All alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die by E6.5. Mice homozygous for a conditional allele activated in the brain exhibit abnormal brain development, neurological defects, and die by P21. Mice homozygous for a conditional allele activated in the liver exhibit premature hepatocyte senescence.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cerebellar granule cell precursor proliferation, proteasome assembly, ...
Component cytoplasm, endoplasmic reticulum, ...
Function proteasome binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (306)    Tissues (105)    Images (35)
Theiler Stages: 13, 15, 17, 18, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 273
Northern blot 17
RT-PCR 16
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(81) cDNA(80) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020398 (Evidence)
Ensembl Gene ModelENSMUSG00000022913 (Evidence)
Entrez Gene56088 (Evidence)
UniGene396248
DFCITC1576415
DoTSDT.493391, DT.99848241
NIA Mouse Gene IndexU037340
Consensus CDS ProjectCCDS28352.1
International Mouse Knockout Project StatusPsmg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020398 VEGA Gene Model | MGI Sequence Detail 11028 C57BL/6J ±  kb
transcript OTTMUST00000048374 VEGA | MGI Sequence Detail 1044 Not Applicable 
polypeptide OTTMUSP00000022152 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016565 Proteasome assembly chaperone 1
Protein Ontology PR:000013397 proteasome assembly chaperone 1
References (Earliest) J:62523 Vidal-Taboada JM, et al., Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation. Biochem Biophys Res Commun. 2000 May 27;272(1):156-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2146658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory