About   Help   FAQ
Psmg1 Gene Detail
Summary
  • Symbol
    Psmg1
  • Name
    proteasome (prosome, macropain) assembly chaperone 1
  • Synonyms
    Dscr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860263
    NCBI Gene: 56088
  • Gene Overview
    MyGene.info: PSMG1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95979954-95990903 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860263
protein coding gene Chr16:95979933-95990960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023078
protein coding gene Chr16:97327639-97340753 (-)
A/J MGP_AJ_G0023046
protein coding gene Chr16:92709448-92720079 (-)
AKR/J MGP_AKRJ_G0023016
protein coding gene Chr16:95575030-95585629 (-)
BALB/cJ MGP_BALBcJ_G0023048
protein coding gene Chr16:93259998-93271672 (-)
C3H/HeJ MGP_C3HHeJ_G0022809
protein coding gene Chr16:96088381-96102402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023495
protein coding gene Chr16:100416082-100426846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020997
protein coding gene Chr16:90569389-90580612 (-)
CAST/EiJ MGP_CASTEiJ_G0022328
protein coding gene Chr16:96886567-96897447 (-)
CBA/J MGP_CBAJ_G0022778
protein coding gene Chr16:104740447-104751259 (-)
DBA/2J MGP_DBA2J_G0022912
protein coding gene Chr16:92600716-92611554 (-)
FVB/NJ MGP_FVBNJ_G0022886
protein coding gene Chr16:91772626-91783452 (-)
LP/J MGP_LPJ_G0022982
protein coding gene Chr16:96955168-96966751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022907
protein coding gene Chr16:108971371-108988487 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023513
protein coding gene Chr16:96105424-96117434 (-)
PWK/PhJ MGP_PWKPhJ_G0022073
protein coding gene Chr16:92889407-92901377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021903
protein coding gene Chr16:95644621-95658021 (-)
WSB/EiJ MGP_WSBEiJ_G0022379
protein coding gene Chr16:96364225-96375796 (-)



Homology
more
  • Human Ortholog
    PSMG1, proteasome assembly chaperone 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSMG1, proteasome assembly chaperone 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21LRP, DSCR2, LRPC21, PAC1, PAC-1
  • Links
    NCBI Gene ID: 8624
    neXtProt AC: NX_O95456
    UniProt: O95456

  • Chr Location
    21q22.2; chr21:39175446-39183514 (-)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die by E6.5. Mice homozygous for a conditional allele activated in the brain exhibit abnormal brain development, neurological defects, and die by P21. Mice homozygous for a conditional allele activated in the liver exhibit premature hepatocyte senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022913 Ensembl Gene Model | MGI Sequence Detail 10950 C57BL/6J ±  kb
    transcript ENSMUST00000023630 Ensembl | MGI Sequence Detail 1044 Not Applicable  
    polypeptide ENSMUSP00000023630 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146658
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Diseases 3
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:62523 Vidal-Taboada JM, et al., Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation. Biochem Biophys Res Commun. 2000 May 27;272(1):156-63
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory