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Psmg1
Gene Detail
Symbol

Name
ID
Psmg1
proteasome (prosome, macropain) assembly chaperone 1
MGI:1860263
Synonyms
Dscr2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
56.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:95979933-95990960 bp, - strand
From VEGA annotation of GRCm38

  11028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2759  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSMG1
Protein SuperFamily: proteasome assembling chaperone-1
Gene Tree: Psmg1

Human
homologs
PSMG1, proteasome (prosome, macropain) assembly chaperone 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8624
neXtProt AC: NX_O95456

Human Synonyms: C21LRP, DSCR2, LRPC21, PAC1, PAC-1

Human Chr (Location): 21q22.3; chr21:39175446-39183514 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
Genomic Mutations involving Psmg1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die by E6.5. Mice homozygous for a conditional allele activated in the brain exhibit abnormal brain development, neurological defects, and die by P21. Mice homozygous for a conditional allele activated in the liver exhibit premature hepatocyte senescence.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Psmg1 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cerebellar granule cell precursor proliferation, proteasome assembly, ...
Component cytoplasm, endoplasmic reticulum, ...
Function proteasome binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (306)    Tissues (105)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 273
Northern blot 17
RT-PCR 16
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psmg1    NEW 
Molecular
reagents
All nucleic(81) cDNA(80) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020398 (Evidence)
Ensembl Gene Model ENSMUSG00000022913 (Evidence)
Entrez Gene 56088 (Evidence)
UniGene 396248
DFCI TC1576415
DoTS DT.493391, DT.99848241
NIA Mouse Gene Index U037340
Consensus CDS Project CCDS28352.1
International Mouse Phenotyping Consortium Status Psmg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020398 VEGA Gene Model | MGI Sequence Detail 11028 C57BL/6J ±  kb
transcript OTTMUST00000048374 VEGA | MGI Sequence Detail 1044 Not Applicable 
polypeptide OTTMUSP00000022152 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016565 Proteasome assembly chaperone 1
Protein Ontology PR:000013397 proteasome assembly chaperone 1
References
(Earliest) J:62523 Vidal-Taboada JM, et al., Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation. Biochem Biophys Res Commun. 2000 May 27;272(1):156-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2146658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory