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Atp11c Gene Detail
Summary
  • Symbol
    Atp11c
  • Name
    ATPase, class VI, type 11C
  • Synonyms
    A330005H02Rik, Ig
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859661
    NCBI Gene: 320940
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:60223283-60404861 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859661
protein coding gene ChrX:60223283-60592698 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035757
protein coding gene ChrX:55585958-55970741 (-)
A/J MGP_AJ_G0035739
protein coding gene ChrX:55782599-56163382 (-)
AKR/J MGP_AKRJ_G0035659
protein coding gene ChrX:57297156-57679205 (-)
BALB/cJ MGP_BALBcJ_G0035726
protein coding gene ChrX:55147085-55531443 (-)
C3H/HeJ MGP_C3HHeJ_G0035428
protein coding gene ChrX:56134954-56516756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036255
protein coding gene ChrX:57077101-57486592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033107
protein coding gene ChrX:55605163-55962826 (-)
CAST/EiJ MGP_CASTEiJ_G0034721
protein coding gene ChrX:41898834-42276240 (-)
CBA/J MGP_CBAJ_G0035403
protein coding gene ChrX:58768954-59180890 (-)
DBA/2J MGP_DBA2J_G0035557
protein coding gene ChrX:55353563-55737213 (-)
FVB/NJ MGP_FVBNJ_G0035507
protein coding gene ChrX:54904663-55275854 (-)
LP/J MGP_LPJ_G0035645
protein coding gene ChrX:56173571-56551235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035543
protein coding gene ChrX:60334611-60739521 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036271
protein coding gene ChrX:55628015-56007997 (-)
PWK/PhJ MGP_PWKPhJ_G0034416
protein coding gene ChrX:40080136-40466105 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034261
protein coding gene ChrX:42743075-43132375 (-)
WSB/EiJ MGP_WSBEiJ_G0034864
protein coding gene ChrX:55094607-55482112 (-)



Homology
more
  • Human Ortholog
    ATP11C, ATPase phospholipid transporting 11C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP11C, ATPase phospholipid transporting 11C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATPIG, ATPIQ, HACXL
  • Links
    NCBI Gene ID: 286410
    neXtProt AC: NX_Q8NB49
    UniProt: Q8NB49

  • Chr Location
    Xq27.1; chrX:139726346-139933083 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATP11C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    7 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for an ENU mutation exhibit decreased B cells associated with arrested adult B cell lymphopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320940 NCBI Gene Model | MGI Sequence Detail 181579 C57BL/6J ±  kb
    transcript NM_001037863 RefSeq | MGI Sequence Detail 6096 C57BL/6  
    polypeptide Q9QZW0 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147864, MGI:2445086
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
    • Latest
      J:248831 Yabas M, et al., ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS One. 2016;11(1):e0146774

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory