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Atp11c
Gene Detail
Symbol

Name
ID
Atp11c
ATPase, class VI, type 11C
MGI:1859661
Synonyms
A330005H02Rik, Ig
Feature Type
protein coding gene
Genetic Map
Chromosome X
33.50 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:60223290-60592698 bp, - strand
From VEGA annotation of GRCm38

  369409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27862  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP11C
Gene Tree: Atp11c

Human
homologs
ATP11C, ATPase, Class VI, type 11C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 286410
neXtProt AC: NX_Q8NB49

Human Synonyms: ATPIG, ATPIQ

Human Chr (Location): Xq27.1; chrX:139726346-139945234 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(4) Gene trapped(4) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous or hemizugous for an ENU mutation exhibit decreased B cells associated with arrested adult B cell lymphopoiesis.
 
Phenotype Images(7)
Interactions
Atp11c interacts with 401 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process lipid transport, phospholipid translocation, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function ATP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (28)    Tissues (3)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498300    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000017557 (Evidence)
Ensembl Gene Model ENSMUSG00000062949 (Evidence)
Entrez Gene 320940 (Evidence)
DFCI TC1641410, TC1608437, TC1578173, TC1680984, TC1771252
DoTS DT.101149325, DT.101734364, DT.111029860, DT.94250410, DT.103572384
NIA Mouse Gene Index U039413
EC 3.6.3.1
Consensus CDS Project CCDS40987.1, CCDS40988.1
International Mouse Phenotyping Consortium Status Atp11c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017557 VEGA Gene Model | MGI Sequence Detail 369409 C57BL/6J ±  kb
transcript OTTMUST00000042662 VEGA | MGI Sequence Detail 6039 Not Applicable 
polypeptide OTTMUSP00000019171 VEGA | MGI Sequence Detail 1129 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(24) UniProt(3)
Polymorphisms
SNPs within 2kb(659 from dbSNP Build 137)    SNPs within 2kb including multiple locations(667)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR023214 HAD-like domain
InterPro IPR006539 Phospholipid-transporting P-type ATPase, subfamily IV
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
Protein Ontology PR:000029288 phospholipid-transporting ATPase IG
References
(Earliest) J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
(Latest) J:216008 Yabas M, et al., Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span. J Biol Chem. 2014 Jul 11;289(28):19531-7
All references(42)
Other
accession IDs
MGI:2147864, MGI:2445086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory