Syt7 MGI Mouse Gene Detail - MGI:1859545

Syt7 Gene Detail

Symbol

Syt7
Name

synaptotagmin VII
Synonyms

B230112P13Rik

Feature Type

protein coding gene
IDs

MGI:1859545
NCBI Gene: 54525
Gene Overview

MyGene.info: SYT7

Sequence Map

Chr19:10389090-10453181 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

64092 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.58 cM, cytoband B
Mapping Data

3 experiments

Human Ortholog

SYT7, synaptotagmin 7

Vertebrate Orthologs

6

Human Ortholog

SYT7, synaptotagmin 7
Orthology source: HomoloGene, HGNC
Synonyms

IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
Links

HGNC:11514

NCBI Gene ID: 9066

neXtProt AC: NX_O43581
Chr Location

11q12.2; chr11:61513716-61588396 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 20889
1 human;1 mouse;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SYT7
Protein SuperFamily

B/K protein/synaptotagmin
Gene Tree

Syt7

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Phenotype Summary

11 phenotypes from 3 alleles in 2 genetic backgrounds
2 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.

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All GO Annotations

40
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

93
Tissues

93
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase syt7

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Syt7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

41
RefSeq

20
UniProt

2
CCDS

CCDS29575.1, CCDS29576.1, CCDS50388.1
UniGene

182654

Ensembl

ENSMUSG00000024743 (Evidence)
NCBI Gene

54525

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024743	Ensembl Gene Model \| MGI Sequence Detail	64092	C57BL/6J	± kb
transcript	ENSMUST00000169121	Ensembl \| MGI Sequence Detail	6834	Not Applicable
polypeptide	ENSMUSP00000127973	Ensembl \| MGI Sequence Detail	567	Not Applicable

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SNPs within 2kb

258 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000015909 synaptotagmin-7
PDB

3N5A
InterPro Domains

IPR000008 C2 domain

IPR001565 Synaptotagmin

IPR015427 Synaptotagmin 7

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 4

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MGI:1925913, MGI:2147618

Summaries

All 58

Developmental Gene Expression 3

Gene Ontology 15

Phenotypes 26
Earliest

J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
Latest

J:228494 Jackman SL, et al., The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016 Jan 7;529(7584):88-91

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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