Syt7 MGI Mouse Gene Detail - MGI:1859545

Symbol

Syt7
Name

synaptotagmin VII
Synonyms

B230112P13Rik

Feature Type

protein coding gene
IDs

MGI:1859545
NCBI Gene: 54525
Gene Overview

MyGene.info: SYT7
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:10389090-10453180 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.58 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859545	protein coding gene	Chr19:10388802-10453181 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024843	protein coding gene	Chr19:7723017-7790564 (+)
A/J	MGP_AJ_G0024811	protein coding gene	Chr19:7197074-7262053 (+)
AKR/J	MGP_AKRJ_G0024786	protein coding gene	Chr19:7479432-7545503 (+)
BALB/cJ	MGP_BALBcJ_G0024811	protein coding gene	Chr19:7243102-7307168 (+)
C3H/HeJ	MGP_C3HHeJ_G0024577	protein coding gene	Chr19:7370619-7437267 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025259	protein coding gene	Chr19:8076864-8144534 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022686	protein coding gene	Chr19:7616499-7680138 (+)
CAST/EiJ	MGP_CASTEiJ_G0024050	protein coding gene	Chr19:7024289-7093471 (+)
CBA/J	MGP_CBAJ_G0024551	protein coding gene	Chr19:8117403-8184978 (+)
DBA/2J	MGP_DBA2J_G0024678	protein coding gene	Chr19:7210193-7274182 (+)
FVB/NJ	MGP_FVBNJ_G0024645	protein coding gene	Chr19:7250671-7316611 (+)
LP/J	MGP_LPJ_G0024765	protein coding gene	Chr19:7694863-7759596 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024672	protein coding gene	Chr19:8023769-8090115 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025307	protein coding gene	Chr19:7500301-7566146 (+)
PWK/PhJ	MGP_PWKPhJ_G0023795	protein coding gene	Chr19:6651091-6716170 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023600	protein coding gene	Chr19:6684936-6749390 (+)
WSB/EiJ	MGP_WSBEiJ_G0024112	protein coding gene	Chr19:7384603-7450353 (+)

Human Ortholog

SYT7, synaptotagmin 7

Vertebrate Orthologs

6

Human Ortholog

SYT7, synaptotagmin 7
Orthology source: HomoloGene, HGNC
Synonyms

IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
Links

HGNC:11514

NCBI Gene ID: 9066

neXtProt AC: NX_O43581

UniProt: O43581
Chr Location

11q12.2; chr11:61513716-61588404 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20889
1 human;1 mouse;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SYT7
Protein SuperFamily

B/K protein/synaptotagmin
Gene Tree

Syt7

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Phenotype Summary

14 phenotypes from 4 alleles in 3 genetic backgrounds
2 images
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.

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All GO Annotations

60
GO References

17

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

93
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syt7

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Syt7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

96
RefSeq

30
UniProt

9
CCDS

CCDS29575.1, CCDS29576.1, CCDS50388.1, CCDS89341.1
UniGene

182654

Ensembl

ENSMUSG00000024743 (Evidence)
NCBI Gene

54525

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024743	Ensembl Gene Model \| MGI Sequence Detail	64091	C57BL/6J	± kb
transcript	ENSMUST00000169121	Ensembl \| MGI Sequence Detail	2116	Not Applicable
polypeptide	ENSMUSP00000127973	Ensembl \| MGI Sequence Detail	687	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000015909 synaptotagmin-7

(term hierarchy)
PDB

3N5A
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR001565 Synaptotagmin

IPR015427 Synaptotagmin 7

IPR037732 Synaptotagmin 7, C2A domain

IPR037741 Synaptotagmin 7, C2B domain

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All nucleic 22

cDNA 20

Primer pair 1

Other 1

Microarray probesets 4

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MGI:1925913, MGI:2147618

Summaries

All 80

Developmental Gene Expression 4

Gene Ontology 17

Phenotypes 42
Earliest

J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
Latest

J:298851 Wang QW, et al., Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31438-31447

TSS for Syt7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155041	Chr19:10388999-10389063 (+)	-59 bp
Tssr155042	Chr19:10389068-10389084 (+)	-14 bp
Tssr5443	Chr19:10389086-10389100 (+)	3 bp
Tssr155043	Chr19:10389205-10389214 (+)	120 bp
Tssr155044	Chr19:10389218-10389233 (+)	136 bp
Tssr155045	Chr19:10389236-10389259 (+)	158 bp
Tssr155046	Chr19:10389270-10389291 (+)	191 bp
Tssr155047	Chr19:10389386-10389441 (+)	324 bp
Tssr155049	Chr19:10426023-10426034 (+)	36,939 bp
Tssr155050	Chr19:10426144-10426157 (+)	37,061 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16