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Syt7 Gene Detail
Summary
  • Symbol
    Syt7
  • Name
    synaptotagmin VII
  • Synonyms
    B230112P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859545
    NCBI Gene: 54525
  • Gene Overview
    MyGene.info: SYT7
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10389090-10453181 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.58 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859545
protein coding gene Chr19:10388781-10453181 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024843
protein coding gene Chr19:7723017-7790564 (+)
A/J MGP_AJ_G0024811
protein coding gene Chr19:7197074-7262053 (+)
AKR/J MGP_AKRJ_G0024786
protein coding gene Chr19:7479432-7545503 (+)
BALB/cJ MGP_BALBcJ_G0024811
protein coding gene Chr19:7243102-7307168 (+)
C3H/HeJ MGP_C3HHeJ_G0024577
protein coding gene Chr19:7370619-7437267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025259
protein coding gene Chr19:8076864-8144534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022686
protein coding gene Chr19:7616499-7680138 (+)
CAST/EiJ MGP_CASTEiJ_G0024050
protein coding gene Chr19:7024289-7093471 (+)
CBA/J MGP_CBAJ_G0024551
protein coding gene Chr19:8117403-8184978 (+)
DBA/2J MGP_DBA2J_G0024678
protein coding gene Chr19:7210193-7274182 (+)
FVB/NJ MGP_FVBNJ_G0024645
protein coding gene Chr19:7250671-7316611 (+)
LP/J MGP_LPJ_G0024765
protein coding gene Chr19:7694863-7759596 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024672
protein coding gene Chr19:8023769-8090115 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025307
protein coding gene Chr19:7500301-7566146 (+)
PWK/PhJ MGP_PWKPhJ_G0023795
protein coding gene Chr19:6651091-6716170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023600
protein coding gene Chr19:6684936-6749390 (+)
WSB/EiJ MGP_WSBEiJ_G0024112
protein coding gene Chr19:7384603-7450353 (+)



Homology
more
  • Human Ortholog
    SYT7, synaptotagmin 7
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SYT7, synaptotagmin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
  • Links
    NCBI Gene ID: 9066
    neXtProt AC: NX_O43581
    UniProt: O43581

  • Chr Location
    11q12.2; chr11:61513716-61588404 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024743 Ensembl Gene Model | MGI Sequence Detail 64092 C57BL/6J ±  kb
    transcript ENSMUST00000076968 Ensembl | MGI Sequence Detail 6624 Not Applicable  
    polypeptide ENSMUSP00000076234 Ensembl | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925913, MGI:2147618
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 4
      Gene Ontology 18
      Phenotypes 36
    • Earliest
      J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
    • Latest
      J:263548 Pradier B, et al., Persistent but Labile Synaptic Plasticity at Excitatory Synapses. J Neurosci. 2018 Jun 20;38(25):5750-5758

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory