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Syt7 Gene Detail
Summary
  • Symbol
    Syt7
  • Name
    synaptotagmin VII
  • Synonyms
    B230112P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859545
    NCBI Gene: 54525
  • Gene Overview
    MyGene.info: SYT7
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:10389090-10453181 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      64092 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.58 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SYT7, synaptotagmin 7
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SYT7, synaptotagmin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
  • Links
    NCBI Gene ID: 9066
    neXtProt AC: NX_O43581
    UniProt: O43581

  • Chr Location
    11q12.2; chr11:61513716-61588404 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    93
  • Tissues
    93
  • cDNA Data
    20
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024743 Ensembl Gene Model | MGI Sequence Detail 64092 C57BL/6J ±  kb
transcript ENSMUST00000076968 Ensembl | MGI Sequence Detail 6624 Not Applicable  
polypeptide ENSMUSP00000076234 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    258 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1925913, MGI:2147618
References
more
  • Summaries
    All 66
    Developmental Gene Expression 4
    Gene Ontology 15
    Phenotypes 32
  • Earliest
    J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
  • Latest
    J:254968 Houy S, et al., Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. Elife. 2017 Dec 23;6(None):None
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory