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Syt7
Gene Detail
Symbol

Name
ID
Syt7
synaptotagmin VII
MGI:1859545
Synonyms
B230112P13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.58 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:10389090-10453181 bp, + strand
From Ensembl annotation of GRCm38

  64092 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20889  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYT7
Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt7

Human
homologs
SYT7, synaptotagmin VII
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9066
neXtProt AC: NX_O43581

Human Synonyms: IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII

Human Chr (Location): 11q12.2; chr11:61513716-61588396 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.
 
Phenotype Images(2)
Interactions
Syt7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component cell junction, cytoplasmic vesicle, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (93)    Tissues (93)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase syt7    NEW 
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024743 (Evidence)
Entrez Gene 54525 (Evidence)
UniGene 182654
DFCI TC1607112, TC1607437, TC1608284, TC1673547, TC1687609
DoTS DT.102555407, DT.110857300, DT.40183341, DT.91336708, DT.97358137, DT.97402640
NIA Mouse Gene Index U019156, U019157, U059733, U269300, U327620
PDB 3N5A
Consensus CDS Project CCDS29575.1, CCDS29576.1, CCDS50388.1
International Mouse Phenotyping Consortium Status Syt7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024743 Ensembl Gene Model | MGI Sequence Detail 64092 C57BL/6J ±  kb
transcript ENSMUST00000169121 Ensembl | MGI Sequence Detail 6834 Not Applicable 
polypeptide ENSMUSP00000127973 Ensembl | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(24) UniProt(6)
Polymorphisms
SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR001565 Synaptotagmin
InterPro IPR015427 Synaptotagmin 7
Protein Ontology PR:000015909 synaptotagmin-7
References
(Earliest) J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
(Latest) J:215808 Dhara M, et al., Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol. 2014 Mar 31;204(7):1123-40
All references(55)
Other
accession IDs
MGI:1925913, MGI:2147618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory