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Syt7
Gene Detail
Symbol

Name
ID
Syt7
synaptotagmin VII
MGI:1859545
Synonyms
B230112P13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.58 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:10389090-10453181 bp, + strand
From NCBI annotation of GRCm38

  64092 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20889  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt7

Human
homologs
Human Homolog SYT7, synaptotagmin VII
NCBI Gene ID 9066
neXtProt AC  NX_O43581
Human Synonyms  IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
Human Chr (Location)  11q12-q13.1; chr11:61513716-61581051 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.
 
Phenotype Images(2)
Interactions
Syt7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process exocytosis, plasma membrane repair, ...
Component cell junction, cytoplasmic vesicle, ...
Function metal ion binding, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (93)    Tissues (93)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024743 (Evidence)
Entrez Gene54525 (Evidence)
UniGene182654
DFCITC1607112, TC1607437, TC1608284, TC1673547, TC1687609
DoTSDT.102555407, DT.110857300, DT.40183341, DT.91336708, DT.97358137, DT.97402640
NIA Mouse Gene IndexU019156, U019157, U059733, U269300, U327620
PDB3N5A
Consensus CDS ProjectCCDS29575.1, CCDS29576.1, CCDS50388.1
International Mouse Knockout Project StatusSyt7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54525 NCBI Gene Model | MGI Sequence Detail 64092 C57BL/6J ±  kb
transcript NM_173068 RefSeq | MGI Sequence Detail 6834 Not Specified 
polypeptide Q9R0N7 UniProt | EBI | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(24) UniProt(6)
Polymorphisms
SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
InterPro IPR015427 Synaptotagmin 7
Protein Ontology PR:000015909 synaptotagmin-7
Graphical View of Protein Domain Structure
References
(Earliest) J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
(Latest) J:207968 Liu H, et al., Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014;3:e01524
All references(54)
Other
accession IDs
MGI:1925913, MGI:2147618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory