Syt7
Gene Detail

Symbol

Name
ID

Syt7
synaptotagmin VII
MGI:1859545

Synonyms

B230112P13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19
6.58 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:10389090-10453181 bp, + strand From Ensembl annotation of GRCm38   64092 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20889  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt7

Human
homologs

Human Homolog		SYT7, synaptotagmin VII
NCBI Gene ID		9066
neXtProt AC		NX_O43581
Human Synonyms		IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
Human Chr (Location)		11q12.2; chr11:61513716-61581051 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.

 
Phenotype Images(2)

Interactions

Syt7 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component	cell junction, cytoplasmic vesicle, ...
Function	calcium-dependent phospholipid binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (93)    Tissues (93)    Images (22)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	93

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000024743 (Evidence)
Entrez Gene	54525 (Evidence)
UniGene	182654
DFCI	TC1687609, TC1673547, TC1608284, TC1607437, TC1607112
DoTS	DT.97402640, DT.97358137, DT.91336708, DT.40183341, DT.110857300, DT.102555407
NIA Mouse Gene Index	U327620, U269300, U059733, U019157, U019156
PDB	3N5A
Consensus CDS Project	CCDS29575.1, CCDS29576.1, CCDS50388.1
International Mouse Knockout Project Status	Syt7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024743	Ensembl Gene Model | MGI Sequence Detail	64092	C57BL/6J
transcript	ENSMUST00000169121	Ensembl | MGI Sequence Detail	6834	Not Applicable
polypeptide	ENSMUSP00000127973	Ensembl | MGI Sequence Detail	567	Not Applicable

All sequences(65) RefSeq(24) UniProt(6)

Polymorphisms

SNPs within 2kb(259 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR001565	Synaptotagmin
InterPro	IPR015427	Synaptotagmin 7
Protein Ontology	PR:000015909	synaptotagmin-7

References

(Earliest) J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
(Latest) J:215808 Dhara M, et al., Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol. 2014 Mar 31;204(7):1123-40
All references(56)

Other
accession IDs

MGI:1925913, MGI:2147618