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Syt7 Gene Detail
Summary
  • Symbol
    Syt7
  • Name
    synaptotagmin VII
  • Synonyms
    B230112P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859545
    NCBI Gene: 54525
  • Gene Overview
    MyGene.info: SYT7
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:10389090-10453181 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      64092 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.58 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SYT7, synaptotagmin 7
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SYT7, synaptotagmin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPCA7, IPCA-7, PCANAP7, SYTVII, SYT-VII
  • Links
    NCBI Gene ID: 9066
    neXtProt AC: NX_O43581
    UniProt: O43581

  • Chr Location
    11q12.2; chr11:61513716-61588404 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have no gross abnormalities or obvious neurological defects. They do develop fibrosis in the skin and skeletal muscle over time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    93
  • Tissues
    93
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024743 Ensembl Gene Model | MGI Sequence Detail 64092 C57BL/6J ±  kb
    transcript ENSMUST00000076968 Ensembl | MGI Sequence Detail 6624 Not Applicable  
    polypeptide ENSMUSP00000076234 Ensembl | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      258 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925913, MGI:2147618
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 34
    • Earliest
      J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
    • Latest
      J:260846 Turecek J, et al., Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses. J Neurosci. 2018 Mar 28;38(13):3240-3251
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory