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Irf7 Gene Detail
Summary
  • Symbol
    Irf7
  • Name
    interferon regulatory factor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859212
    NCBI Gene: 54123
  • Gene Overview
    MyGene.info: IRF7
Location & Maps
more
  • Sequence Map
    Chr7:141262706-141266481 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3776 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.57 cM, cytoband F5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IRF7, interferon regulatory factor 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF7, interferon regulatory factor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IMD39, IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H
  • Links
    NCBI Gene ID: 3665
    neXtProt AC: NX_Q92985

  • Chr Location
    11p15.5; chr11:612553-615999 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IRF7 associations

Human Disease Mouse Models
       Immunodeficiency 39; IMD39   OMIM: 616345
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Irf7
  • Incidental Mutations
Homozygous null mice are more vulnerable to viral infection and exhibit decreased serum interferon levels in response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024538 VEGA Gene Model | MGI Sequence Detail 3776 C57BL/6J ±  kb
transcript OTTMUST00000060229 VEGA | MGI Sequence Detail 1916 Not Applicable  
polypeptide OTTMUSP00000029373 VEGA | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002049 interferon regulatory factor 7
  • PDB
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR017855 SMAD domain-like
    IPR008984 SMAD/FHA domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 96
    Genomic 1
    cDNA 94
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 125
    Developmental Gene Expression 9
    Gene Ontology 12
    Phenotypes 80
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228986 Temizoz B, et al., TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol. 2015 Apr;45(4):1159-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory