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Irf7
Gene Detail
Symbol

Name
ID
Irf7
interferon regulatory factor 7
MGI:1859212
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.57 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141262706-141266481 bp, - strand
From VEGA annotation of GRCm38

  3776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF7
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf7

Human
homologs
IRF7, interferon regulatory factor 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3665
neXtProt AC: NX_Q92985

Human Synonyms: IMD39, IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H

Human Chr (Location): 11p15.5; chr11:612553-615999 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IRF7

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are more vulnerable to viral infection and exhibit decreased serum interferon levels in response to viral infection.
 
Interactions
Irf7 interacts with 62 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process immune system process, immunoglobulin mediated immune response, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (127)    Tissues (124)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 124
Northern blot 3
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase irf7 ; ZFIN irf7    NEW 
Molecular
reagents
All nucleic(96) Genomic(1) cDNA(94) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024538 (Evidence)
Ensembl Gene Model ENSMUSG00000025498 (Evidence)
Entrez Gene 54123 (Evidence)
UniGene 3233
DFCI TC1572544, TC1772855
NIA Mouse Gene Index U029451
PDB 3QU3
Consensus CDS Project CCDS22005.1, CCDS57594.1, CCDS57595.1
International Mouse Phenotyping Consortium Status Irf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024538 VEGA Gene Model | MGI Sequence Detail 3776 C57BL/6J ±  kb
transcript OTTMUST00000060229 VEGA | MGI Sequence Detail 1916 Not Applicable 
polypeptide OTTMUSP00000029373 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002049 interferon regulatory factor 7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222321 Edwards CL, et al., Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. Eur J Immunol. 2015 Jan;45(1):130-41
All references(119)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory