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Keap1
Gene Detail
 Symbol
Name
ID
Keap1
kelch-like ECH-associated protein 1
MGI:1858732
Synonyms INrf2, mKIAA0132, ring canal protein
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.74 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21229730-21239332 bp, - strand
From NCBI annotation of GRCm38

  9603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Keap1

Human
homologs
Human Homolog KEAP1, Kelch-like ECH-associated protein 1
NCBI Gene ID 9817
neXtProt AC  NX_Q14145
Human Synonyms  INrf2, KLHL19
Human Chr (Location)  19p13.2; chr19:10486120-10503378 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(19) Targeted(6)
 
Homozygous null mice exhibit scaly skin, hyperkeratosis of the esophagus and stomach mucosa, and die around 3 weeks of age, putatively due to malnutrition resulting from the abnormal alimentary epithelium.
 
Interactions
Keap1 interacts with 105 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular response to interleukin-4, cytoplasmic sequestering of transcription factor, ...
Component cell-cell adherens junction, Cul3-RING ubiquitin ligase complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 15, 19
Assay TypeResults
RNA in situ 3
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(139)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003308 (Evidence)
Entrez Gene50868 (Evidence)
UniGene248266
DFCITC1572270, TC1587403, TC1601174, TC1604819
DoTSDT.101737127, DT.110607505, DT.40173834, DT.495102, DT.97333284
NIA Mouse Gene IndexU030573
PDB1X2J, 1X2R, 2DYH, 3ADE, 3WDZ, 2Z32, 3WN7
Consensus CDS ProjectCCDS22897.1
International Mouse Knockout Project StatusKeap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50868 NCBI Gene Model | MGI Sequence Detail 9603 C57BL/6J ±  kb
transcript NM_016679 RefSeq | MGI Sequence Detail 4470 C57BL/6 
polypeptide Q9Z2X8 UniProt | EBI | MGI Sequence Detail 624 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR015916 Galactose oxidase, beta-propeller
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000009277 kelch-like ECH-associated protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
(Latest) J:209004 Yagishita Y, et al., Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 2014 Feb;63(2):605-18
All references(99)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory