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Keap1
Gene Detail
Symbol

Name
ID
Keap1
kelch-like ECH-associated protein 1
MGI:1858732
Synonyms
INrf2, mKIAA0132, ring canal protein
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.74 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21229730-21239332 bp, - strand
From VEGA annotation of GRCm38

  9603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KEAP1
Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Keap1

Human
homologs
KEAP1, Kelch-like ECH-associated protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9817
neXtProt AC: NX_Q14145

Human Synonyms: INrf2, KLHL19

Human Chr (Location): 19p13.2; chr19:10486120-10503378 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(19) Targeted(6)
 
Homozygous null mice exhibit scaly skin, hyperkeratosis of the esophagus and stomach mucosa, and die around 3 weeks of age, putatively due to malnutrition resulting from the abnormal alimentary epithelium.
 
Interactions
Keap1 interacts with 105 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase keap1 ; ZFIN keap1a, keap1b    NEW 
Molecular
reagents
All nucleic(139) cDNA(139)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050608 (Evidence)
Ensembl Gene Model ENSMUSG00000003308 (Evidence)
Entrez Gene 50868 (Evidence)
UniGene 248266
DFCI TC1572270, TC1587403, TC1601174, TC1604819
DoTS DT.97333284, DT.495102, DT.110607505, DT.40173834, DT.101737127
NIA Mouse Gene Index U030573
PDB 1X2J, 1X2R, 3ADE, 2DYH, 3WDZ, 2Z32, 3WN7
Consensus CDS Project CCDS22897.1
International Mouse Phenotyping Consortium Status Keap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050608 VEGA Gene Model | MGI Sequence Detail 9603 C57BL/6J ±  kb
transcript OTTMUST00000128317 VEGA | MGI Sequence Detail 2163 Not Applicable 
polypeptide OTTMUSP00000069043 VEGA | MGI Sequence Detail 624 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR015916 Galactose oxidase, beta-propeller
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000009277 kelch-like ECH-associated protein 1
References
(Earliest) J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
(Latest) J:222136 Fukutomi T, et al., Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. Mol Cell Biol. 2014 Mar;34(5):832-46
All references(106)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory