Celsr3
Gene Detail

Symbol Name ID

Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) MGI:1858236

Synonyms

flamingo, Fmi1, mKIAA0812

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:108826320-108852963 bp, + strand From Ensembl annotation of GRCm38   26644 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr3

Human homologs

Human Homolog		CELSR3, cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Gene ID		1951
neXtProt AC		NX_Q9NYQ7
Human Synonyms		CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
Human Chr (Location)		3p21.31; chr3:48673896-48700348 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	axonal fasciculation, cell adhesion, ...
Component	integral to membrane, membrane, ...
Function	calcium ion binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (321)    Tissues (123)    Images (59)
Theiler Stages: 8, 9, 11, 12, 15, 16, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	321

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023473 (Evidence)
Entrez Gene	107934 (Evidence)
UniGene	39945
DFCI	TC1597040
DoTS	DT.55207070
NIA Mouse Gene Index	U040725
Consensus CDS Project	CCDS23539.1
International Mouse Knockout Project Status	Celsr3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023473	Ensembl Gene Model | MGI Sequence Detail	26644	C57BL/6J
transcript	ENSMUST00000024238	Ensembl | MGI Sequence Detail	11541	Not Applicable
polypeptide	ENSMUSP00000024238	Ensembl | MGI Sequence Detail	3301	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR015919	Cadherin-like
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR022624	Domain of unknown function DUF3497
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
InterPro	IPR000203	GPS domain
InterPro	IPR001791	Laminin G domain
Protein Ontology	PR:000005320	cadherin EGF LAG seven-pass G-type receptor 3

References

(Earliest) J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
(Latest) J:190932 Feng J, et al., A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. J Neurosci. 2012 Oct 3;32(40):13729-43
All references(42)