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Celsr3
Gene Detail
Symbol

Name
ID
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
MGI:1858236
Synonyms
Adgrc3, flamingo, Fmi1, mKIAA0812
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:108826320-108852969 bp, + strand
From VEGA annotation of GRCm38

  26650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CELSR3
Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr3

Human
homologs
CELSR3, cadherin, EGF LAG seven-pass G-type receptor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1951
neXtProt AC: NX_Q9NYQ7

Human Synonyms: ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1

Human Chr (Location): 3p21.31; chr3:48636463-48662915 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.
 
Interactions
Celsr3 interacts with 303 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process axonal fasciculation, cell adhesion, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (321)    Tissues (131)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 321
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase celsr3 ; ZFIN celsr3    NEW 
Molecular
reagents
All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050676 (Evidence)
Ensembl Gene Model ENSMUSG00000023473 (Evidence)
Entrez Gene 107934 (Evidence)
UniGene 39945
DFCI TC1597040
DoTS DT.55207070
NIA Mouse Gene Index U040725
Consensus CDS Project CCDS23539.1
International Mouse Phenotyping Consortium Status Celsr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050676 VEGA Gene Model | MGI Sequence Detail 26650 C57BL/6J ±  kb
transcript OTTMUST00000129250 VEGA | MGI Sequence Detail 11547 Not Applicable 
polypeptide OTTMUSP00000069455 VEGA | MGI Sequence Detail 3301 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(15) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS domain
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005320 cadherin EGF LAG seven-pass G-type receptor 3
References
(Earliest) J:61652 Formstone CJ, et al., Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9. Mamm Genome. 2000 May;11(5):392-4
(Latest) J:221606 Han Q, et al., Plasticity of motor network and function in the absence of corticospinal projection. Exp Neurol. 2015 May;267:194-208
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory