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Celsr3
Gene Detail
 Symbol
Name
ID
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
MGI:1858236
Synonyms flamingo, Fmi1, mKIAA0812
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:108826320-108852963 bp, + strand
From Ensembl annotation of GRCm38

  26644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr3

Human
homologs
Human Homolog CELSR3, cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Gene ID 1951
neXtProt AC  NX_Q9NYQ7
Human Synonyms  CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
Human Chr (Location)  3p21.31; chr3:48636463-48662915 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.
 
Interactions
Celsr3 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axonal fasciculation, cell adhesion, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (321)    Tissues (131)    Images (59)
Theiler Stages: 8, 9, 11, 12, 15, 16, 17, 19, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 321
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023473 (Evidence)
Entrez Gene107934 (Evidence)
UniGene39945
DFCITC1597040
DoTSDT.55207070
NIA Mouse Gene IndexU040725
Consensus CDS ProjectCCDS23539.1
International Mouse Knockout Project StatusCelsr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023473 Ensembl Gene Model | MGI Sequence Detail 26644 C57BL/6J ±  kb
transcript ENSMUST00000024238 Ensembl | MGI Sequence Detail 11541 Not Applicable 
polypeptide ENSMUSP00000024238 Ensembl | MGI Sequence Detail 3301 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(15) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS domain
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005320 cadherin EGF LAG seven-pass G-type receptor 3
References (Earliest) J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
(Latest) J:207433 Han Q, et al., Spinal cord maturation and locomotion in mice with an isolated cortex. Neuroscience. 2013 Dec 3;253:235-44
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory