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Rab25
Gene Detail
Symbol

Name
ID
Rab25
RAB25, member RAS oncogene family
MGI:1858203
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.87 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:88542029-88548300 bp, - strand
From VEGA annotation of GRCm38

  6272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22995  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB25
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab25

Human
homologs
RAB25, RAB25, member RAS oncogene family
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57111
neXtProt AC: NX_P57735

Human Synonyms: CATX-8, RAB11C

Human Chr (Location): 1q22; chr1:156061175-156070504 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
On a 129 background, virgin female homozygotes older than 10 months of age develop vaginal cancer while both male and female homozygotes develop distal esophageal stricture due to squamous cell hyperplasia.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Rab25 interacts with 35 markers (Mir10a, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process epithelial cell morphogenesis, exocytosis, ...
Component cell projection, cytoplasmic vesicle, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (74)    Tissues (14)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab25 ; ZFIN rab25a    NEW 
Molecular
reagents
All nucleic(54) Genomic(1) cDNA(53)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027246 (Evidence)
Ensembl Gene Model ENSMUSG00000008601 (Evidence)
Entrez Gene 53868 (Evidence)
UniGene 26994
DFCI TC1579845, TC1665136
DoTS DT.491728, DT.101141389, DT.94154472
NIA Mouse Gene Index U024257
Consensus CDS Project CCDS17477.1
International Mouse Phenotyping Consortium Status Rab25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027246 VEGA Gene Model | MGI Sequence Detail 6272 C57BL/6J ±  kb
transcript OTTMUST00000067368 VEGA | MGI Sequence Detail 1081 Not Applicable 
polypeptide OTTMUSP00000033887 VEGA | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013598 ras-related protein Rab-25
References
(Earliest) J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
(Latest) J:198884 Senga K, et al., Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug;23(15):2845-55
All references(34)
Other
accession IDs
MGI:2139927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory