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Exosc9
Gene Detail
 Symbol
Name
ID
Exosc9
exosome component 9
MGI:1355319
Synonyms p5, p6, Pmscl1, PM/Scl-75, RRP45
Feature Type protein coding gene
Genetic Map
Chromosome 3
17.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:36552606-36565729 bp, + strand
From VEGA annotation of GRCm38

  13124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3693  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Exosc9

Human
homologs
Human Homolog EXOSC9, exosome component 9
NCBI Gene ID 5393
neXtProt AC  NX_Q06265
Human Synonyms  p5, p6, PMSCL1, PM/Scl-75, RRP45, Rrp45p
Human Chr (Location)  4q27; chr4:121801290-121817021 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Exosc9 interacts with 94 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, nuclear mRNA surveillance, ...
Component cytoplasm, exosome (RNase complex), ...
Function AU-rich element binding, exonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (3)   
Theiler Stages: 3, 11, 13
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000002113 (Evidence)
Ensembl Gene ModelENSMUSG00000027714 (Evidence)
Entrez Gene50911 (Evidence)
DFCITC1591540, TC1598557, TC1662401
Consensus CDS ProjectCCDS17312.1
International Mouse Knockout Project StatusExosc9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002113 VEGA Gene Model | MGI Sequence Detail 13124 C57BL/6J ±  kb
transcript OTTMUST00000004267 VEGA | MGI Sequence Detail 1619 Not Applicable 
polypeptide OTTMUSP00000002019 VEGA | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001247 Exoribonuclease, phosphorolytic domain 1
InterPro IPR015847 Exoribonuclease, phosphorolytic domain 2
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000007266 exosome complex component RRP45
References (Earliest) J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory