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Uchl3
Gene Detail
Symbol

Name
ID
Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
MGI:1355274
Feature Type
protein coding gene
Genetic Map
Chromosome 14
50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:101653967-101696124 bp, + strand
From Ensembl annotation of GRCm38

  42158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UCHL3
Protein SuperFamily: ubiquitin thiolesterase
Gene Tree: Uchl3

Human
homologs
UCHL3, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7347
neXtProt AC: NX_P15374

Human Synonyms: UCH-L3

Human Chr (Location): 13q22.2; chr13:75548867-75606020 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(31) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null animals show degeneration in dorsal root ganglia. Mice display postnatal progressive retinal degeneration and muscular degeneration. In combination with a knockout of ubiquitin C-terminal hydrolase L1, neurological effects of each are accelerated, mice are dysphagic and die younger.
 
Interactions
Uchl3 interacts with 53 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process adult walking behavior, cellular response to insulin stimulus, ...
Component cytoplasm, extracellular exosome, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase uchl3 ; ZFIN uchl3    NEW 
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022111 (Evidence)
Entrez Gene 50933 (Evidence)
UniGene 275970
DFCI TC1583631, TC1591114
EC 3.4.19.12
Consensus CDS Project CCDS27313.1
International Mouse Phenotyping Consortium Status Uchl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022111 Ensembl Gene Model | MGI Sequence Detail 42158 C57BL/6J ±  kb
transcript ENSMUST00000002289 Ensembl | MGI Sequence Detail 929 Not Applicable 
polypeptide ENSMUSP00000002289 Ensembl | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Protein Ontology PR:000017025 ubiquitin carboxyl-terminal hydrolase isozyme L3
References
(Earliest) J:61093 Kurihara LJ, et al., Expression and functional analysis of Uch-L3 during mouse development. Mol Cell Biol. 2000 Apr;20(7):2498-504
(Latest) J:175529 Dennissen FJ, et al., Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). FEBS Lett. 2011 Aug 19;585(16):2568-74
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory