Uchl3
Gene Detail

Symbol Name ID

Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) MGI:1355274

Feature Type

protein coding gene

Genetic Map

Chromosome 14

50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:101653967-101696124 bp, + strand From Ensembl annotation of GRCm38   42158 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin thiolesterase
Gene Tree: Uchl3

Human homologs

Human Homolog		UCHL3, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
NCBI Gene ID		7347
neXtProt AC		NX_P15374
Human Synonyms		UCH-L3
Human Chr (Location)		13q22.2; chr13:76123616-76180156 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(33) : Targeted(2) Gene trapped(31)
 

Homozygous null animals show degeneration in dorsal root ganglia. Mice display postnatal progressive retinal degeneration and muscular degeneration. In combination with a knockout of ubiquitin C-terminal hydrolase L1, neurological effects of each are accelerated, mice are dysphagic and die younger.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	adult walking behavior, cellular response to insulin stimulus, ...
Component	cytoplasm, intracellular, ...
Function	cysteine-type peptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022111 (Evidence)
Entrez Gene	50933 (Evidence)
UniGene	275970
DFCI	TC1583631, TC1591114
EC	3.4.19.12
Consensus CDS Project	CCDS27313.1
International Mouse Knockout Project Status	Uchl3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022111	Ensembl Gene Model | MGI Sequence Detail	42158	C57BL/6J
transcript	ENSMUST00000002289	Ensembl | MGI Sequence Detail	929	Not Applicable
polypeptide	ENSMUSP00000002289	Ensembl | MGI Sequence Detail	230	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001578	Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
Protein Ontology	PR:000017025	ubiquitin carboxyl-terminal hydrolase isozyme L3

References

(Earliest) J:61093 Kurihara LJ, et al., Expression and functional analysis of Uch-L3 during mouse development. Mol Cell Biol. 2000 Apr;20(7):2498-504
(Latest) J:175529 Dennissen FJ, et al., Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). FEBS Lett. 2011 Aug 19;585(16):2568-74
All references(39)