About   Help   FAQ
Copb2 Gene Detail
Summary
  • Symbol
    Copb2
  • Name
    coatomer protein complex, subunit beta 2 (beta prime)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354962
    NCBI Gene: 50797
  • Gene Overview
    MyGene.info: COPB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:98563721-98588382 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24662 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.40 cM, cytoband E3-F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    COPB2, coatomer protein complex subunit beta 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COPB2, coatomer protein complex subunit beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    beta'-COP, MCPH19
  • Links
    NCBI Gene ID: 9276
    neXtProt AC: NX_P35606
    UniProt: P35606

  • Chr Location
    3q23; chr3:139355595-139389680 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Copb2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000047583 VEGA Gene Model | MGI Sequence Detail 24662 C57BL/6J ±  kb
    transcript OTTMUST00000122715 VEGA | MGI Sequence Detail 3050 Not Applicable  
    polypeptide OTTMUSP00000067228 VEGA | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      225 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 273
      cDNA 272
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143003
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:42235 Hosaka M, et al., Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996 Oct;120(4):813-9
    • Latest
      J:252710 DiStasio A, et al., Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. Hum Mol Genet. 2017 Sep 19;None(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory