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Copb2 Gene Detail
Summary
  • Symbol
    Copb2
  • Name
    coatomer protein complex, subunit beta 2 (beta prime)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354962
    NCBI Gene: 50797
  • Gene Overview
    MyGene.info: COPB2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98563731-98588375 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.40 cM, cytoband E3-F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354962
protein coding gene Chr9:98563721-98588382 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035156
protein coding gene Chr9:99868736-99894974 (+)
A/J MGP_AJ_G0035138
protein coding gene Chr9:96363046-96388165 (+)
AKR/J MGP_AKRJ_G0035069
protein coding gene Chr9:98728026-98752858 (+)
BALB/cJ MGP_BALBcJ_G0035130
protein coding gene Chr9:96042922-96067584 (+)
C3H/HeJ MGP_C3HHeJ_G0034840
protein coding gene Chr9:99108292-99132861 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035650
protein coding gene Chr9:102733144-102757270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032549
protein coding gene Chr9:94125761-94150768 (+)
CAST/EiJ MGP_CASTEiJ_G0034151
protein coding gene Chr9:98913310-98938476 (+)
CBA/J MGP_CBAJ_G0034808
protein coding gene Chr9:106258150-106286494 (+)
DBA/2J MGP_DBA2J_G0034970
protein coding gene Chr9:95869457-95892739 (+)
FVB/NJ MGP_FVBNJ_G0034918
protein coding gene Chr9:94699996-94723076 (+)
LP/J MGP_LPJ_G0035049
protein coding gene Chr9:100122798-100147002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034957
protein coding gene Chr9:108195313-108220044 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035672
protein coding gene Chr9:98935813-98962191 (+)
PWK/PhJ MGP_PWKPhJ_G0033858
protein coding gene Chr9:96081834-96106021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033694
protein coding gene Chr9:98996529-99021745 (+)
WSB/EiJ MGP_WSBEiJ_G0034271
protein coding gene Chr9:98816899-98841549 (+)



Homology
more
  • Human Ortholog
    COPB2, coatomer protein complex subunit beta 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COPB2, coatomer protein complex subunit beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    beta'-COP, MCPH19
  • Links
    NCBI Gene ID: 9276
    neXtProt AC: NX_P35606
    UniProt: P35606

  • Chr Location
    3q23; chr3:139355595-139389680 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Copb2 mouse models; 1 with human COPB2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50797 NCBI Gene Model | MGI Sequence Detail 24645 C57BL/6J ±  kb
    transcript NM_015827 RefSeq | MGI Sequence Detail 3043 NOD  
    polypeptide O55029 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 274
      cDNA 273
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143003
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:42235 Hosaka M, et al., Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996 Oct;120(4):813-9
    • Latest
      J:252710 DiStasio A, et al., Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. Hum Mol Genet. 2017 Dec 15;26(24):4836-4848

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory